Filming started in November of 2017. However, due to Blake Lively's hand injury in December 2017, filming was halted in February 2018 for Lively's recovery and resumed in June 2018. The film's release date was also delayed at least twice. It was originally scheduled for a 22 February 2019 release, before being delayed 10 months, then being rescheduled again, for release on 31 January 2020.
One long take of a car chase took almost a week to shoot.
During a brutal fight sequence between Jude Law (B) and Blake Lively (Stephanie) that was filmed in just one take after weeks of preparation, Blake broke her hand after delivering a punch to Jude's chest. It is a case of "life imitating art," because in the book, Stephanie Patrick breaks her fingers, though in a different way. The "piece-of-glass-in-Stephanie's-hand" event, was added to a different fight scene, so that Blake Lively could act later scenes with that hand bandaged up.
As seen on a newspaper clipping, the number of people killed, 239, on the ill-fated flight is the same number as were on real-life Malaysian Air Flight MH370.