Space Dandy is simply awesome. It manages to stand out by focusing more on being entertaining than anything else. Most anime these days focus each episode on continuing an ever-evolving story that spans the whole series. Space Dandy, however, spends each episode telling a self- contained, stand alone story. The basic premise, which is explained in the pilot episode, is that Space Dandy is searching the universe for new aliens to register and earn a reward. Each following episode just shows the crew's encounters with different aliens and situations. Like I said, there isn't much episode-to-episode continuity, but each episode is meant to be extremely enjoyable, and it succeeds there.
As of this writing, the series still isn't over. If anything drastically changes throughout the course of the series, i'll update this review.