The amount of money that Susan Sarandon says she has, $6700, is the same amount she had in Thelma and Louise.
The plot was based on a dream Ben Falcone had, dreaming about his wife Melissa McCarthy as a fast food worker whose life is falling apart. The two later wrote plot points on napkins before developing the screenplay.
There is only 24 years difference in age between Melissa McCarthy (Tammy) and Susan Sarandon (Tammy's grandmother, Pearl). Furthermore, there is only 11 years difference between McCarthy and Allison Janney, who plays her mother.