Director trademark: Using vintage automobiles in a futuristic setting.
The film takes place in 2169.
Many of the character names are those of famous, and not so famous, watchmakers. The name Weis is pronounced the same as the watchmaker Albert Wajs.
In a movie about people who would stop aging at 25 years old, many of the actors, including Cillian Murphy and Justin Timberlake, were in their late 20s and early 30s. Amanda Seyfried, however, really was 25 years old during filming.
Amanda Seyfried claimed that the most difficult thing about shooting the film was that she often had to full-on run while wearing high-heeled shoes. She would have removed her shoes for those scenes, but it would have been impossible for her to be barefoot on the concrete roads that she had to run across.