Don't let the title scare you away, 'Jeff, Who lives At Home' is a deep character study about three unhappy people and the meaningless existences they each inhabit.
One such person is Pat (Ed Helms), a man stuck in a roller coaster of a relationship with his wife, Linda (Judy Greer). Pat has recently purchased any man's dream car, a brand new Porsche. Judy doesn't share in his delight for his new automobile, which only distances them even more. When Pat suspects Linda of having an affair, it leads him on a inept detective mysterious, where most of the films humor draws on.
Susan Sarandon plays Sharon, the mother of Pat. A widower, Sharon is very lonely and loans for someone to connect with. When a "secret admirer" begins sending her flirty messages, Sharon is delightfully surprised someone is still interested in her despite her age. It's up to Sharon to uncover this mystery person's identity.
The last chapter, the title character, is played by Jason Segal. By far the best part of the movie, Jeff is a slacker in his 30's with no real aim in life. After seeing the movie 'Signs' and having someone with the wrong number call him and ask for a Kevin, he believes it to be a sign. The rest of his arc delves into him following after all things tied to "Kevin," and the strange paths it takes him.
A common misconception I can see being falling into is that this will be a broad, raunchy comedy, like the ones Ed Helm and Jason Segal have headlined in their career. If you go into this film expecting that, you'll be disappointed. This is a thinking man's movie, with smart humor and likable characters sprinkled in. With your time.