The Kardos family is thrown into disarray when Covid-19 hits New York and the parents are quarantined in Italy. The four sisters, two of whom have different mothers, must figure out adulthood and begin to make their living, and also are left with a bigger mystery of their family's ancestry and the history of Manhattan. Through flashbacks, the film spans 23 years in the lives of the dysfunctional and multi-racial Kardos family, culminating in the traumatic events of 2020. The four sisters each have their own traumas and arcs, from struggles with anxiety and mental illness to global pandemics, the murder of George Floyd, and protests in Washington. The Sisters Kardos is a film that celebrates womanhood and sisterhood, focusing on the emerging Gen-Z voice. It is also a love-letter to New York.
—anonymous