The central tagline, "Gobble, gobble, motherf*cker!", was thought of before the movie's actual plot.
No one wanted to distribute the film at first, so the filmmakers sold the DVD on Amazon themselves. It took a year to sell 1,000 copies.
The infamous opening scene with Wanda Lust was shot without a permit in a public park.
The title card "To be continued in space..." was placed in the movie as a complete joke, with no intention of any sequels. Nonetheless, a sequel, ThanksKilling 3 (2012), was released three years later.
ThanksKilling was shot during the summer break between Kevin Stewart and Jordan Downey's junior and senior year of college.