Fortiche Productions made a music video named "Get Jinxed" for Riot in 2013. It already features Jinx and the city of Piltover. Riot was so impressed by the work that they asked Fortiche to make an animated series, which took them several years to create. After the release of season one, Riot announced that there will be a second season and that it will take less time to produce.
The goggles Claggor wears in Arcane are the same goggles Vi wears on her head in-game for Riot's League of Legends, Legends of Runeterra, and other games.
Last role of actress Mira Furlan, who voices Babette. She passed away in January of 2021.
In episode 6, Marcus daughter's children's book has pictures of league of legends champion, Teemo.
Imagine Dragons and JID did an official animated music video for League of Legends, a few days before Arcane released on Netflix. The visuals focus on life in the undercity.