Claremont Psychiatric Hospital is fictional. Its exterior shots belong actually to the Findlay Teller Apartments in the Bronx, New York City.
In September 2019 Fox gave freshman Prodigal Son a full season order. The network has ordered an additional 9 episodes bringing the show's first season to a total of 22 episodes. The serial killer drama was the most watched new program of premiere week in adults 18-49.
Michael Sheen has said in an online interview that he found being handcuffed and tethered for most of his scenes useful because it solved the common issue actors have of not knowing what to do with his hands.
Cancellation of Prodigal Son after 2 seasons was announced on May 10th, 2021, with 2 episodes remaining in the 2nd season, and much to the disappointment of fans who immediately launched petitions and trending the hashtag #SaveProdigalSon on Twitter to try and save the show.
Tom Payne is 12 years younger than Bellamy Young who plays his mother and 11 years older than Halston Sage who plays his sister.