Before playing a supporting role in this show, Pamela Sue Martin starred in The Hardy Boys/Nancy Drew Mysteries (1977) as Nancy Drew.
Shortly after filming began on the pilot episode, Scott Wolf replaced Freddie Prinze Jr. as Nancy's father Carson.
There's a close-up shot of a street sign that says River Heights Drive. In the books, River Heights was the name of the town where Nancy Drew lived.
Keene High School is named after "Carolyn Keene", the collective pseudonym used by the ghostwriter authors of the original Nancy Drew books.
The original title of the series was "The Haunting of Nancy Drew" before it was shortened to "Nancy Drew".