This is the first Time Crisis (1995) video game series ever to feature an additional game mode with FPS (first-person shooter) controls. Namco Bandai Games' light gun control the Guncon 3 is specially crafted for that control style.
This is the first Time Crisis (1995) video game series to feature character voiced dialogues heard during the time when the player is shooting the enemies. The previous Time Crisis (1995) video game series had no dialogues during the time when the player is shooting the enemies.
This is the first Time Crisis (1995) main series to feature a story that has nothing to do with rescuing any captured or kidnapped characters. All the previous main series of Time Crisis (1995) always involves rescuing captured or kidnapped characters.