I really like this show.
People have complained that because it's from the creators of Sex & The City and Friends, that it should be amazing. No one will remark that the first four episodes of those shows were groundbreaking. But for someone looking for a replacement of those great shows, you will be disappointed. Someone looking for a great show about family, you will be pleasantly pleased.
Related is ensemble cast driven, giving fair time to each actress. I think the story lines are funny, thoughtful and have a lot of room to expand for many seasons. I like that the four sisters have distinct personalities and dialog. The highlight is Jennifer Espisito. She plays a very warm, caring older sister. It's much different than what I've seen in her before, and she does it well.
I am a girl that grew up with all brothers and when I watch this show, I instantly connect with the images I have had my whole life of having sisters.
Related is great!