I admit to a certain prejudice here since I lived with a live action version of Fang for 9 years, but Dave may in fact be the most underrated animated series of the past 20 years. Sarcastic, witty and sly, Dave skewers modern fantasy and it's fandom with a zeal not often seen outside an episode of South Park. Dave,a beautiful steroid enhanced muscle man with the heart of the Cowardly Lion, and his two sisters, Fang, a tiny redhead with a big voice and a habit of getting her own way come hell or high water, and Candy, the fairy tale princess left in charge of the kingdom while mom and dad are off fighting evil, deal with Candy's addiction to shopping, defeat the Dark Lord Chuckles (a cute little piggie), engage in sibling rivalry, and in general just struggle to grow up and accept responsibility.
My best guess as to the lack of an audience for this gem is that the targeted demographic, the average fantasy fan and SciFi addict, lacks even a vestigial sense of humor. Dealing with the target group in a sarcastic manner only works if the members of that group are able to engage in enough abstract reasoning to appreciate being made the butt of the joke.