Chuck analyzes a strange Moon rock concealed by NASA and finally gets some answers. Angela is kidnapped. A cop falsely suspects Kurt. Sarah's wish comes true - as well as her worst nightmare. The show ends on an unresolved cliffhanger.
Five astronauts are sole survivors of an inexplicable apocalyptic event that caused Earth to suddenly blow up. An alien AI construct that's investigating similar incidents arrives and sends them five years into the past to stop the event.
The crew tries to prevent the suicide of a notable mathematician who developed sentient AI programs. Sarah and Angela investigate a suspicious gene therapy treatment. Neil returns to high school and meets his now underage girlfriend.
The Odyssey 5 team forms an alliance with a friendly geeky sentient, who calls himself Harry Mudd and has a great lust for life, to stop a powerful insane female sentient, who plans to destroy Earth.
Neil is being stalked by Kit-10, an insane all-powerful female AI. Sarah loses her visitation rights. Angela is on a new joint space mission with a friendly Russian astronaut, Tatianna Kosviskova. Kit-10 uses them as hostages.
Chuck gets infected by a synthetic and starts turning into one. The other synthetics want him to join them. Sarah tries to get joint custody of her son, after his father takes him away. Marc is tested by his supervisor.
Man-made artificially intelligent synthetic organism that imitates human skin and can attach itself to a person and take them over jumps from one person to another in an attempt to kill Angela's father. Chuck's worst nightmare comes true.
Chuck, Kurt and Sarah infiltrate a private high tech prison called Lock Down Unit 7 to find the convict who claims that the people he killed were synthetic replicas of his parents. Neil's brother is having identity crisis.
The crew has visions of people asking them if they believe that anything is possible. This leads to Chuck and Neil confronting a painful memory, Sarah dealing with her son's cancer and Kurt and Angela seeing the future they could've had.
