Paul Gertz, one of the head writers on the show has said that the extent of Gene Roddenberry's involvement in the creation of the show was a premise written on a napkin in a lockbox full of obscure notes written on things like receipts, scraps of paper. Out of that small note, they created the show.
The show is famous for the unusually high turnover rate among the regular cast, partially due to contractual disagreements between the cast and the producers. Almost all of the show's major characters were killed or otherwise removed within a season or two of being introduced. In fact, the only character to appear as a regular during all five seasons was FBI Agent Ronald Sandoval (Von Flores), the show's main antagonist.
On the desk of Dr. Julianne Belman, played by Majel Barrett, is a picture of Gene Roddenberry, Barrett's husband and creator of the concept for the series.
The original title for the show was "Battleground: Earth", but the producers changed it because it sounded too much like L. Ron Hubbard's novel, "Battlefield: Earth".