Trivia

Shandling based the show on his experience as the Monday night guest host of The Tonight Show Starring Johnny Carson (1962) from 1986 to 1987. Shandling was offered numerous deals to host his own late-night talk show, but turned them all down.

David Duchovny's appearances on the show focused on his attraction to Larry. This is a joke that has outlived the Sanders show itself, resurfacing, among other places, on The X-Files (1993) (in the episode "Hollywood A.D." Garry Shandling, appears as himself, Scully (Gillian Anderson) comments to Mulder (David Duchovny) "I think that Téa Leoni has a little crush on you...I think that Shandling likes you a bit too."), and in a skit filmed for The 56th Annual Primetime Emmy Awards (2004).

The first cable series to receive an Emmy nomination for Best Comedy Series.

Part of the reason cast members from Seinfeld (1989) did cameos on the show is because both productions shared the same production facility in Studio City, California.

Originally, a real studio audience was used for the talk show scenes. But sometimes the scenes would take several hours to shoot, which was tough on the audience. Eventually, they stopped having an audience, unless the episode needed crowd reaction shots. A laugh track was used instead.