While searching for a serial killer, Nick Knight discovers a chance to end his vampire curse. While Schanke tracks down leads in the human world, Nick learns that the murder may be the work of the man who made him a vampire 700 years ago.
Nick comes face to face with the vampire LaCroix and kills him. But the serial murders continue and get personal when it is discovered that one of the victims was a friend of Nick's.
A young doctor dies, and all evidence points to suicide, and one of Nick's "old friends" (another vampire) commits suicide. Nick suspects the doctors death to be a murder, while contemplating the nature of suicide.
A pop radio psychiatrist is horrified because one of her call-in listeners commits murder while she is on the air and Nick helps her get her confidence back.