Lou is a young preacher dude, one that doesn't remember his entire family being massacred when was child, mainly due to him taking a bullet to the head. Now he's a travelling preacher with his adopted family and his quasi-sister, who stupidly runs off to join a dancing troupe. This means that Lou will have to go after her, with only a bible to begin with.
Lou quickly realizes that he's deadly shot while during a robbery in the street, he picks up a gun from a corpse and effortlessly kills two raiders with it. Lou finds out that his half-sister Princy has become a whore, and pimped by one of the guys who was present when his family where massacred, and his boss is the vampire like Mark Damon, who's character has a lot of space to move around in. This is not your usual Western, even if the basic plot is.
Franco Citti's character likes to rub a little doll on his face, Lou and Mark have a shooting contest, shooting out candle flames while drinking. Lou has to hide inside a bell while people throw bombs at him. There's also a duel where Lou and another guy stand on stools with nooses round their necks and tries to shoot the legs off the stool before the other does. Most of the actual emotional stuff comes from Mark Damon, who has trouble with his wife, gets riled at the mess caused by his men, and might even be gay.
I've read somewhere that this is some kind of communist Western, but that's up to others to figure out.