Raymond Burr injured his eyes working on the series. Being in a wheelchair, he had to look up directly into the hot lights used to film his scenes, and his eyes were slightly burned.
This series' distinctive theme music was made by Quincy Jones, it was among the first such high profile assignments for the now-legendary composer.
In the pilot, Ironside wears a bandage on his right hand. This was not make-up. Raymond Burr injured the first two fingers of his hand when he fell after being "shot".
As the show progressed, Mark went from being Ironside's bodyguard to a full fledged police officer, and eventually became an attorney in the final season. In "The Return of Ironside" (1993), he had become a judge.
NBC abruptly cancelled the series in 1975 without airing three episodes: "The Organizer", "The Rolling Y", and "A Matter of Life or Death". They eventually aired in syndication.