Originally Kharis the mummy, another Universal "classic monster", was to be in the movie but was removed because of budget restrictions.
The three villages that figure in Universal's Frankenstein saga get rather confusing. Frankenstein (1931), Bride of Frankenstein (1935), and Son of Frankenstein (1939), take place in or near the village of Frankenstein. In The Ghost of Frankenstein (1942), The Monster and Ygor travel from Frankenstein to the village of Vasaria, where Frankenstein Meets the Wolf Man (1943) takes place. However--in a geographical disconnect--in "House of Frankenstein," The Monster and The Wolf Man are found in ice near the village of Frankenstein. They are revived and move on to the village of Visaria.
The sequence in which the shadow of Dracula transforms into a vampire bat was directed by Universal Pictures' resident animation maven Walter Lantz, who also created the studio's most popular cartoon star, Woody Woodpecker.
In his scenes with John Carradine, Peter Coe described in an interview how Carradine found ways to upstage him and steal the scene. After Coe confronted and threatened him if it happened again, he said Carradine became more co-operative and professional.
Bela Lugosi was slated for the role of Dracula, but the film was dependent upon the presence of Boris Karloff being released from the stage tour of Arsenic and Old Lace (1944). Shooting was delayed, and John Carradine was cast instead of Lugosi, who had a prior engagement: ironically, playing Karloff's "Jonathan Brewster" role in another touring company of "Arsenic and Old Lace."