- In 2007, Lily-Rose was hospitalized for a serious e.coli infection which led to acute kidney failure. Her father, who was in the middle of shooting "Sweeney Todd," halted filming so that he may be by her side as she recuperated. Depp later donated around $2 million to Great Ormond Street Hospital to show his gratitude.
- Daughter of Johnny Depp and Vanessa Paradis.
- Lily-Rose is fluent in both English and French.
- Johnny Depp has Lily-Rose's name tattooed on his chest over his heart.
- Lily-Rose Depp is good friends with Harley Quinn Smith, the daughter of director/filmmaker Kevin Smith. The two girls, who co-star in Smith's film Yoga Hosers (2016), met in kindergarten.
- Has struggled with Anorexia and has recovered healthier.
- Has dual French and U.S. citizenship.
- Godsister of Helena Bonham Carter and Tim Burton's son Billy Ray Burton.
- Marilyn Manson is her godfather.
- In the language of flowers, Lily-Rose's name evokes opposing characteristics. The lily, the birth flower for the month of May, is associated with virtue and chastity. The white lily is often used as a symbol of the Virgin Mary's holiness and purity. The rose, symbolic of love and passion, is closely associated with Aphrodite and Venus, the Roman and Greek goddesses of love.
- While numerous social media sites have been dedicated to the young ingénue, her parents, actor Johnny Depp and French signer Vanessa Paradis, have tried to keep their children out of the limelight. While there are numerous social media profiles that purport to be Lily-Rose, they're all fake except for her official Instagram account. Photos and videos posted to the web have been pilfered from the Facebook, Instagram, and Vine profiles belonging to her friends.
- Johnny Depp gave her the name Lily-Rose to tribute his mother Betty-Sue.
- She went to pre-school with actress Harley Quinn Smith.
- Although she was too young to vote, she supported Sen. Bernie Sanders during the 2016 presidential election.
- Called "Nepo Baby" by New York Magazine for her head start in her acting career, due to her parents; Johnny Depp and Vanessa Paradis. Which she previously denied in Elle magazine by comparing nepotism to a scenario of becoming a doctor.
- Niece of Alysson Paradis.
- She was passed a "joint" at a party when she was 13 years old.
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