- He did his own stunts in action drama "The K2". He underwent special training in martial arts for his role as an elite bodyguard."The K2" was was the first Korean drama to use the Matrix-style "Bullet Time effect" and showcased various fighting techniques such as jujistsu, aikido and taekwondo. The actor performed all of his stunts and did not use a body double. In an interview with Sports Chosun, he said that this was the most strenuous project he had done so far and he was going to take a break from action scenes for the time being.
- He advocates for disability rights. The prolific actor collaborated with MIRAL Welfare Foundation, a non-governmental organization for a campaign named "How You See Me?". It promotes the acceptance of the civil rights of the disabled citizens of South Korea and aims to reduce stigma and prejudice.
- When asked on a television interview if there was any actor he had kissed more than Park Min Young (his co-star in "Healer"), he revealed that he kissed fellow actor Kang Ha Neul in their 2010 musical "Thrill Me" so many times over three months of performances that he lost count. According to Chang Wook, "We really kissed a lot. And it was not just any kiss. They were all very deep passionate kisses." "Thrill Me" was the two-man musical. Kang Ha Neul played Nathan Leopold alongside Ji Chang Wook's Richard Loeb. It was staged from May 14 to November 14, 2010 at The Stage, Sinchon, Seoul. It was based on a true story of a murder case in Chicago and touched on topics such as homosexuality and criminal behavior. It tells the story of how two men tried to commit the perfect crime and thought they could get away with it. The two men, Nathan Leopold and Richard Loeb were called "thrill killers" and their story was told in flash backs.
- He is an only child. His dad passed away when he was an Elementary school. So, it is only him and his mom. That is also why he is a proud mama's boy.
- He knows how to play the piano and is a good singer, having sung many songs in his film/Tv soundtracks.
- He knows how to knit and cross-stitch. He learned this ability to play his character Mi-Poong in the "The Sons of Sol Pharmacy House".
- He loves animals, especially dogs. He has a dog named Ggoma.
- He speaks Mandarin.
- He enlisted in the military on August 14, 2017 and was discharged on April 27, 2019 with the rank of Sergeant.
- He loves to exercise. As a student, he played soccer and basketball, and in his middle school swimming class, he used to swim a lot in the swimming pool at their school on the basement level.
- Before pursuing his career as an actor, when he was in high school, he wanted to be an engineer and work in architecture. When he was even younger, his dream jobs included a police officer, a judge, a lawyer, a doctor and a teacher.
- Despite domestic successes with his roles in daily drama "Smile Again" and action historical drama "Warrior Baek Dong Soo", it was not until the highly-acclaimed "Empress Ki" series, which was hugely popular both locally and internationally, that he started gaining increased popularity and recognition for his acting skills. His next drama "Healer" enhanced his popularity overseas and kickstarted his career in China.
- He began his career in musical theatre. When auditioning for department of theatre and film of Dankook University, he sang a song from Les Mis for the performance part of the test. He made his onscreen debut in the 2006 film "Days" and had a minor role in the 2008 television drama "You Stole My Heart".
- According to Soompi, he maintains a close friendship with a group of other celebrities which include Kim Rae Won, Choi Jong Hun, and Choi Tae Joon.
- He officially debuted in 2008 through the film, "Sleeping Beauty".
- The actor has appeared in several music videos, including solo singer K.Will's "I Need You" and female singer Younha's "We Broke Up Today". He has also appeared in popular K-pop girl group T-ara's "Cry Cry" and "Lovey Dovey" as well as boy group SPEED's "That's My Fault" and "It's Over".
- Before he graduated, he attended Shin Sung High School. Then, He went to Dankook University and he majored in Theather and Films.
- He once claimed that he had a huge crush on famous Korean actress Song Hye-kyo.
- Chang Wook contracted coronavirus in 2021 when he was filming one of his drama series.
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