- Was twice nominated for Broadway's Tony Award as Best Actor in a Musical: for The Full Monty in 2001 and for the role of Curly in Oklahoma in 2002.
- Stated that Tom Hanks was his inspiration for becoming an actor.
- A New York Yankees fan, Wilson sang "God Bless America" a cappella during the seventh-inning stretch at Yankee Stadium during the 2010 playoffs.
- Wilson has a tattoo of the letters KPW on his arm for the initials of his first son.
- Before being cast in Watchmen (2009), he auditioned for roles in two other comic book-based movies, Fantastic Four (2005) and Daredevil (2003).
- Was a soloist with the Mostly Pops Orchestra and Canton Symphony Orchestra.
- His wife, Dagmara Dominczyk, gave birth to their first son, Kalin Patrick Wilson on June 23, 2006 and to their second son, Kassian McCarrell Wilson, on August 9, 2009.
- Good friends with Vera Farmiga.
- Wilson is of English, Scottish, Scots-Irish/Northern Irish, German and Welsh ancestry. His father, John, and his brother, Mark, are both TV anchormen at WTVT in Tampa, Florida. His mother, Mary Kathryn (nee Burton), is a professional singer and voice teacher. Brother-in-law of Veronika Dominczyk and Marika Dominczyk (and the latter's husband, Scott Foley).
- He was awarded the 1996 Drama Logue Award for Performance for "Carousel" in the Royal National Theatre production at the Ahmanson Theatre in Los Angeles, California.
- Has appeared in three different films based on DC Comics properties: He played Dan Dreiberg/Nite Owl in Watchmen (2009) and the United States President in Batman v Superman: Dawn of Justice (2016), and as Orm/Ocean Master in Aquaman (2018).
- Wilson was awarded the Charles Willard Memorial Award for Undergraduate Excellence in Music Theatre while studying at Carnegie-Mellon. He graduated in 1995 with a BFA in drama. Wilson's college roommate, Matthew Stocke, was later his understudy in the stage musical "The Full Monty".
- He received an honorary Doctor of Fine Arts from Trinity College in Hartford, Connecticut, U.S.A. He was also the Commencement Speaker at the 185th Commencement Exercise at Trinity College on May 22, 2011.
- Starring with John Lithgow, Dianne Wiest, and Katie Holmes in Broadway's "All My Sons". (September 2008)
- Plays on the Broadway Show League baseball team.
- Plays the drums.
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