- Is the first regular cast member on Saturday Night Live (1975) to be born after the show first premiered.
- As of 2017, Kenan Thompson holds the record for the show's longest-tenured cast member on Saturday Night Live, as he is currently in his 15th season on SNL, and Darrell Hammond (who held the record before him) only stuck around for 14 seasons.
- Reprised three of his All That (1994) roles on its 10th Anniversary Special: Lester Oaks: Construction Worker, Principal Pimpel, and Pierre Escargot, whom he mentions is his favorite character.
- Kenan currently holds the record for most impressions done on SNL.
- His first impression on Saturday Night Live (1975) was of Bill Cosby, which he did regularly on All That (1994).
- Was on weight-loss program before getting the lead role in Fat Albert (2004). Afterward, he had to gain the weight back.
- Good friends with Kel Mitchell. Best friends with Nick Cannon.
- Has played both "Fat Albert", in the live-action movie, Fat Albert (2004), and the show's creator, Bill Cosby, which he has done several times, including on a Celebrity Jeopardy sketch on Saturday Night Live (1975).
- A fan favorite recurring role on Saturday Night Live (1975) is Kenan Thompson's "Diondre Cole", a BET talk-show host: "What Up with That?" His character never allows guests to be interviewed because "Diondre Cole" always interrupts them - breaking out into a song and dance number with a bizarre and comedic ensemble cast.
- Had to wear a fat suit for the character Fat Albert (2004) for the title character.
- Nominated for the 2018 Emmy Award in the Supporting Actor in a Comedy Series category for his various roles in Saturday Night Live (1975), but lost to Henry Winkler from Barry (2018).
- On May 9, 2015 (just 30 minutes before Mother's Day), Kenan Thompson, his Saturday Night Live (1975) co-stars, and host Reese Witherspoon appeared alongside their mothers in the opening monologue. That year, Mother's Day coincided with Kenan Thompson's birthday, making it all the more a very special occasion for him and his mother.
- He was awarded a Star on the Hollywood Walk of Fame for Television at 6627 Hollywood Boulevard in Hollywood, California on August 11, 2022. J.B. Smoove, Leslie Jones and Josh Server were guest speakers at the ceremony.
- The series on which he stared, All That (1994), aired exactly 20 years after Saturday Night Live (1975) aired. He would go on to star in the latter eight years later.
- He holds the record for the longest-running cast member on Saturday Night Live (1975) for 18 seasons. He broke the previous record of 14 seasons which was held by Darrell Hammond.
- As a child, he was a huge fan of The Price is Right (1972) which he referred to as "my first love" and "very joyful viewing", which had an effect of his future acting style.
- Currently resides in Los Angeles, California and New York City.
- He is half of the comedic duo Kenan & Kel with Kel Mitchell.
- Nominated for the 2020 Primetime Emmy Award for Outstanding Supporting Actor in a Comedy Series, but lost to Dan Levy. Dan would later appear on Saturday Night Live (1975) for which he was nominated for Outstanding Guest Actor in a Comedy Series.
- Is a huge fan of the Atlanta Falcons football team.
- Shares the same birth date and birthplace with actress Corri English.
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