- Although suffering from aviatophobia (fear of flying), he portrayed war pilot Manfred von Richthofen in The Red Baron (2008).
- Is fluent in German and English and has basic knowledge in French.
- Due to his phobia of flying, he never flies within Germany. He always drives. Every time he flies outside of Germany, he has to talk to his therapist before boarding the plane.
- Lives in Berlin.
- Plays the piano and the violin.
- Is often teased about his uncanny resemblance to Game of Thrones (2011) character Brienne of Tarth played by British actress Gwendoline Christie.
- He loves writing poems and his favorite author is Max Frisch.
- His role in Rabbit Without Ears (2007) was one of the last roles in the movie to be cast. Til Schweiger mentioned that he simply couldn't find a suitable actor for the role as Moritz the paparazzi, so he let his friend Matthias Schweighöfer audition for it and eventually had found a suitable actor.
- Son of actor Michael Schweighöfer and actress Gitta Schweighöfer.
- Enjoys running and swimming.
- Studied acting at the School of Theater "Ernst Busch" in Berlin.
- Godfather of his daughter Greta is Silbermond drummer Andreas Nowak.
- Provided his voice for the part of Thomas in the German version of Tom Tykwer's True (2004).
- Had to cut his hair for his part in Rabbit Without Ears (2007).
- Collaborated with Jessica Schwarz in Friends of Friends (2002), Cold Spring (2004), Kammerflimmern (2004) and Lulu (2006).
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