- Wrestled for the United States at the 1920 Olympic Games in Antwerp, Belgium, earning a silver medal, and lost only one match due to a controversial point-decision. After the Games he became a professional wrestler and was a big fan favorite, which led to Hollywood.
- According to Mike Chapman in his article on Pendleton in Classic Images (May 2015), Nat was a direct descendant of Revolutionary War hero General Nathanael Greene, who won key victories over the British. It also is reported that Pendleton is a distant relative of "Star-Spangled Banner" composer Francis Scott Key.
- He was usually cast as a circus strongman, brutish thug, dumb cop or dense buffoon, but he had a college degree and in 1933 wrote the script for Deception (1932), in which he starred--not surprisingly--as a wrestler.
- A voracious reader, he wrote poetry, played the banjo and was an avid chess player.
- On the 1920 census he was living in Manhattan with his Puerto Rican first wife Juanita Alfonzo (age 22) and her brother Ramon Alfonso (age 13). He was working as a sports manager.
- Auditioned for the role of Tarzan for MGM but lost out to Johnny Weissmuller.
- Former Olympic wrestler turned actor.
- Never smoked and seldom drank.
- Two-time Eastern Intercollegiate Wrestling Association (EIWA) champion (1914-1915) in the 175-lb class while at Columbia University, from which he graduated in 1916.
- Was in three Oscar Best Picture nominees: Lady for a Day (1933), The Thin Man (1934) and The Great Ziegfeld (1936), with The Great Ziegfeld winning in 1936.
- Inducted into the Columbia University Athletics Hall of Fame in 2006 (inaugural class).
- Member of the Delta Epsilon fraternity at Columbia University.
- Upon his death, his remains were interred at Cypress View Mausoleum and Crematory in San Diego, California. His location plot is Corridor A NW, #9 on the inside of the door frame on the left side.
- Two brothers: Steven Gaylord and Edmund.
- The chef in 'Crazy House' (1930) is played by Karl Dane, and not Pendleton.
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