- Was not originally scheduled to play Ebenezer Scrooge in the MGM classic version of A Christmas Carol (1938). Reginald was a last-minute replacement for the ailing Lionel Barrymore.
- His Bel-Air mansion at 356 St. Pierre Road was rented out to The Beatles in August 1964, while they were performing at the Hollywood Bowl, after the Ambassador Hotel in Los Angeles had canceled their reservations.
- Known for his vast portrayals of fictional and non-fictional fellows. Played Dr. Watson in Sherlock Holmes (1932), and then played the super-sleuth himself in A Study in Scarlet (1933), joining Jeremy Brett, Carleton Hobbs, and Patrick Macnee as the only actors to play both roles. Also played King Louis XV in three different films.
- Returned to Broadway in 1972, the year he died, in the Phil Silvers-led production of "A Funny Thing Happened on the Way to the Forum.".
- Was in the process of writing his autobiography at the time of his death.
- Appeared in seven Best Picture Oscar nominees: The House of Rothschild (1934), A Tale of Two Cities (1935), The Great Ziegfeld (1936), Mrs. Miniver (1942), Random Harvest (1942), National Velvet (1944) and Mary Poppins (1964). The Great Ziegfeld and Mrs. Miniver both won.
- Graduated from Tree's Academy of Dramatic Art.
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