- She (as Raquel DeMarco) and Erika Eleniak both made their Playboy modeling debuts in the same issue - the February 1989 Playboy Newstand Special (aka Playboy's Great Playmate Hunt, The Women of Playboy's 35th Anniversary Search).
- Cast to play the "Italian Mafia Princess" on WOW: WOW: Women of Wrestling (2000), but did not appear in the final roster.
- Parents: singer Arlene DeMarco, of the singing group The DeMarco Sisters, and actor Keefe Brasselle.
- Daughter (with Rob Sanchez): actress/singer Hayley Sanchez, born 1998.
- Aunts: Terri DeMarco, Anne DeMarco, Gloria DeMarco, and Jeanette DeMarco, who (together with Arlene DeMarco) made up the singing group The DeMarco Sisters.
- Winner, Fox Reality Channel Really Award for "Favorite Meltdown" for her appearance in I Know My Kid's a Star (2008). (2008)
- Uncles: actors Murray Hamilton and Remo Pisani.
- Cousin: actor/stuntman/composer Stephen Pisani.
- Met her future partner, Rob Sanchez, on the set of Loved (1997).
- In a co-parenting relationship with Rob Sanchez, father of her daughter, Hayley Sanchez.
- Ex-partner of stuntman Rob Sanchez.
- Appeared with her daughter, Hayley Sanchez, on the first episode of "Dr. Drew On Call [2011]", discussing child stars.
- Melissa and both of her parents, Arlene DeMarco and Keefe Brasselle, were born under the sun sign of Aquarius. Remarkably, Melissa's only child, Hayley Sanchez, is also an Aquarius.
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