- The Pentagon named a Stealth computer system "Elvira" inspired by her.
- Was scalded by boiling water when she was five years old. Underwent 17 skin grafting operations over the course of her childhood to repair the scar tissue. Now covers some of her remaining scars (around neck and shoulders) with make-up or clothing.
- Was close friends with Vincent Price.
- Owns a production company in Los Angeles called Queen B Productions. She merchandises Elvira products.
- Although she has appeared in nude layouts, she has never appeared nude as Elvira, Mistress of the Dark.
- She was the stripper in the background on the cover of Tom Waits' album "Small Change" (1976). She has since described it as a "giant mystery" claiming that while she has no memory of the event, the cover looks enough like her that she feels "pretty sure" that it is her.
- Maila Nurmi, the original Vampira, once sued her for stealing her character without consulting her. However, Peterson claimed that Elvira was nothing like Vampira aside from the basic design of the black dress and black hair.
- Ranked #1 of Sci-Fi's Sexiest B-Queens, by Femme Fatales magazine (1997).
- Her favorite movies are Plan 9 from Outer Space (1957) and Attack of the Killer Tomatoes! (1978).
- In 2002, she licensed the name and likeness of Elvira to International Game Technologies for use in an Elvira-themed video slot machine.
- Is the first woman who had done a music video in 3D ("Superstition").
- Has hosted the Halloween themed amusement park Knott's Scary Farm in Buena Park, California, from 1982 - 2001.
- In 2012, she became an investor in Comikaze Entertainment Inc., which hosts Comikaze Expo, one of the largest popular culture conventions of the United States. She was also inducted into the Horror Host Hall of Fame, as her character Elvira, Mistress of the Dark.
- Former member of the improvisational comedy group The Groundlings.
- In 1981, she auditioned for the role of Ginger Grant for the third "Gilligan's Island" television movie, shortly before KHJ-TV offered her the horror-host position. She was also a personality on the Los Angeles radio station KROQ-FM 106.7 from 1982 - 1983.
- In 1989, she licensed the name and likeness of Elvira to Midway Manufacturing (a division of WMS Gaming) for the pinball game "Elvira and the Party Monsters".
- In 1996, she licensed the name and likeness of Elvira to Midway Manufacturing (a division of WMS Gaming) for the pinball game "Scared Stiff".
- In 2022, Cassandra Peterson - "Elvira" was a runner up in the category of Favorite Horror Host of 2021 in the 20th Annual Rondo Hatton Classic Horror Awards.
- Attended and graduated from Palmer High School in Colorado Springs, Colorado (1969).
- In a romantic relationship with Teresa Wierson since 2002. She wrote about this in her book "Yours Cruelly, Elvira" (2021).
- Has one daughter: Sadie Pierson (born October 12, 1994).
- Is close friends with heavy metal musician Rob Zombie.
- Released a coffee table book of photos taken through her career titled "Elvira, Mistress of the Dark" on October 5, 2016.
- She served as the inspiration for the character Barbara "Booberella" Lelavinsky on The Simpsons.
- She is a lifelong Democrat.
- Released her autobiography, "Yours Cruelly, Elvira: Memoirs of the Mistress of the Dark", on September 21, 2021, after its initial release in October 2020 was delayed.
- In 1968, she was hired as a dancer and showgirl in Las Vegas when she was age 17. She quit when her contract was done a year later.
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