Penny Marshall and Rosie O'Donnell in Saturday Night Live (1975)

Rosie O'Donnell in Beautiful Girls (1996)

Rosie O'Donnell and Frankie Shaw in SMILF (2017)

Rosie O'Donnell in Miss Representation (2011)

Rosie O'Donnell, Jordan Rodrigues, Maia Mitchell, and David Lambert in The Fosters (2013)

Rosie O'Donnell and Hayden Byerly in The Fosters (2013)

Tom Hanks, Madonna, and Rosie O'Donnell in A League of Their Own (1992)

Tom Hanks and Rosie O'Donnell in A League of Their Own (1992)

Tom Hanks, Rosie O'Donnell, and Justin Scheller in A League of Their Own (1992)

Rosie O'Donnell, Ana Gasteyer, Maggie Q, Bobby Moynihan, Pete Wentz, and Tituss Burgess in Match Game (2016)

Adam Goldberg, Rosie O'Donnell, Ana Gasteyer, Horatio Sanz, Sherri Shepherd, and Tituss Burgess in Match Game (2016)

Rosie O'Donnell in The 42nd Annual Grammy Awards (2000)

Sharon Gless and Rosie O'Donnell in Queer as Folk (2000)

Rosie O'Donnell and Jacqueline Toboni in Little Boxes (2022)

Rosie O'Donnell and Brian Baumgartner in Rosie O'Donnell & Brian Baumgartner (2022)

Rosie O'Donnell and Joseph Cross in Wide Awake (1998)

Uma Thurman, Matt Dillon, Lauren Holly, Timothy Hutton, Michael Rapaport, and Rosie O'Donnell in Beautiful Girls (1996)

John Goodman, Rick Moranis, Elizabeth Perkins, and Rosie O'Donnell in The Flintstones (1994)

Stephen Baldwin, Mel Blanc, John Goodman, Rick Moranis, Elizabeth Perkins, Mark Addy, Kristen Johnston, Jane Krakowski, Rosie O'Donnell, Elizabeth Daily, Harvey Korman, Hlynur Sigurðsson, Marinó Sigurðsson, Elaine Silver, and Melanie Silver in The Flintstones (1994)

Rosie O'Donnell and Michelle Trachtenberg in Harriet the Spy (1996)

Demi Moore, Christina Ricci, Thora Birch, Melanie Griffith, Gaby Hoffmann, Rita Wilson, Rosie O'Donnell, and Ashleigh Aston Moore in Now and Then (1995)