- Speaks Mandarin Chinese and English fluently. She also speaks a bit of Japanese and Italian.
- Practices rock climbing, skiing, and horseback riding.
- Her mother is a biochemist; her father works as a civil engineer.
- Plays the accordion.
- In 2000, she became the first Asian-American female to host Saturday Night Live (1975).
- Has had gallery exhibitions, showing her collage, paintings and photography.
- Has a son: Rockwell Lloyd Liu (b. August 27, 2015).
- As her family spoke Mandarin Chinese at home, she did not learn English until the age of 5.
- Currently resides in New York with her brother Alex Liu and his wife.
- Received her Bachelor's degree in Asian Languages and Cultures from the University of Michigan at Ann Arbor.
- She once worked as an aerobics instructor.
- Attended and graduated from New York's prestigious Stuyvesant High School (1986).
- Grew up in the Jackson Heights section of Queens County, New York.
- Very involved in the plight of pediatric AIDS in Africa.
- Auditioned for the role of Elektra in Daredevil (2003), but lost out to Jennifer Garner.
- Was named a U.S. Fund for UNICEF Ambassador (2005).
- Mentioned in the song "Hey Ya" by the hip hop duo Outkast.
- Chosen by Goldsea Asian American Daily as one of the "100 Most Inspiring Asian Americans of All Time" (ranked #51).
- In 1991, Liu underwent surgery after a breast cancer scare. After a check up with her doctor where a lump was found, she was immediately admitted into the hospital for surgery to remove the it. The lump was found to be benign.
- She was awarded a Star on the Hollywood Walk of Fame for Television at 1708 Vine Street in Hollywood, California on May 1, 2019. Is the second Asian American woman to be honored a star on the Hollywood Walk of Fame. The first was Anna May Wong. Their stars are adjacent to each other.
- Is an initiated sister of Chi Omega Fraternity.
- Auditioned for a role in Shanghai Knights (2003), but lost out to Fann Wong.
- Ranked #56 in FHM's "100 Sexiest Women in the World 2005" special supplement (2005).
- Attended New York University for a year.
- One of the guests at Ashton Kutcher's and Demi Moore's wedding (2005).
- She is depicted in an episode of Futurama (1999).
- Announced that she plans on marrying Zach Helm, her boyfriend of one year. (April 2004)
- Award of Merit for voice-over in "The No Name Painting Association" at the Best Shorts Competition 2013.
- Ranked #79 in FHM magazine's "100 Sexiest Women in the World 2006" supplement (2006).
- She is a Vegetarian.
- Graduated from Stuyvesant High School the same year as Yelba Zoe McCourt and Zorikh Lequidre.
- Considers herself a multitasker.
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