Trivia

Children: Molly Tambor (b. 1975); Gabriel Kasper (b. December 10, 2004), Eve Julia (December 10, 2006), Hugo Bernard and Eli Nicholas (twins b. October 4, 2009) with wife Kasia. Daughter Molly gave birth to his grandson (Mason Jay Moore) four days before his son Gabriel was born.

Has played multiple characters on the situation comedy Three's Company (1976).

Teaching fellow/graduate assistant at Wayne State University in Detroit, Michigan in the late 1960s.

Reportedly, the first actor to use the C-word on TV which he did on The Hankerciser 200 (1993) when referring to Larry's wife as "that c--t". Jeffrey was supposed to say "bitch", but in rehearsals he improvised and Garry Shandling opted for the C-word instead.

Was a teacher at Milton Katselas' Beverly Hills Playhouse.

In February 2018, Amazon Studios fired Tambor from the series Transparent after multiple allegations of sexual harassment against the actor arose. Amazon, who owns and produces the Soloway series, had been investigating the actor and made an official decision for Tambor not to have any role in Season 5.

His paternal grandparents, Ignatz and Mollie, were Hungarian Jewish immigrants. His maternal grandparents, Joseph and Gertrude, were Ukrainian Jews (from Kiev).

He originally played Tom Abernathy in Miss Congeniality 2: Armed & Fabulous (2005). However, when the scene needed to be reshot, he was shooting Arrested Development (2003), so the scene was reshot with Stephen Tobolowsky. The version of the scene with Jeffrey can be seen on the DVD.

He appeared in Phil Collins' music video of his song "I Wish It Would Rain Down" (1990).

Directed a production of "Burn This" at the Skylight Theatre in Los Angeles and is the co-owner of Skylight Books in the Los Feliz area.

He was nominated for a 1974 Joseph Jefferson Award for Best Actor in a Principal Role for his performance in "The Play's the Thing", at the Goodman Theatre in Chicago, Illinois.

He was awarded a Star on the Hollywood Walk of Fame for Television at 6320 Hollywood Boulevard in Hollywood, California on August 8, 2017.

He was awarded the 1982 Drama Logue Award for Outstanding Performance in "A Flea in Her Ear", at the Mark Taper Forum Theatre in Los Angeles, California.

In 2008, he purchased a four-bed, five bath, 3,591 square foot home in Topanga, California for $1.675 million.

In 2007, he sold his five-bedroom, Cape Cod-style house in Los Angeles' Pacific Palisades neighborhood for $3.3 million. In early 2005, he had purchased the house for $2,749,000.