- According to a 2001 interview with The Calgary Sun, he credits Robert De Niro with turning his life around during the filming of Witness to the Mob (1998). De Niro showed up on his doorstep with Tom's mother and told him they were there to drive him to jail or rehab. He chose rehab.
- Had his nose accidentally broken by Juliette Lewis during the filming of the prison cell fight scene in Oliver Stone's Natural Born Killers (1994).
- Auditioned six times for the part of Mr. Pink in Reservoir Dogs (1992).
- In February 2005, he failed a court-ordered drug test after he was caught trying to use a prosthetic penis to fake the results, the second time he has been caught trying this.
- To prepare for Natural Born Killers (1994), Tom met with Ted Bundy's psychiatrist and John Wayne Gacy.
- Claims to have spent $11 million on lawyers and legal fees fighting previous drug and domestic violence charges.
- Wrote the stand-off scene between "Horvath" and "Reiben" in Saving Private Ryan (1998).
- Spent time doing research at Folsom Prison, a maximum security facility near Sacramento, California to gather insider insight into the criminal psychology and felonious crews like the fictional one his character belongs to in Heat.
- Tom credits his ex-wife Maeve Quinlan, a professional tennis player and a regular on The Bold and the Beautiful (1987), with helping to keep him on the straight and narrow, she was always there to steer him straight.
- Tom features in the longest "walk 'n talk" scene in movie history, as "Jack Scagnetti" in Natural Born Killers (1994).
- Tom is the godfather of Michael Madsen's youngest child, Hudson.
- As a struggling young actor in New York, Sizemore worked for three years as a waiter in the World Trade Center.
- Arrested in Los Angeles, after his wife, Maeve Quinlan, called police claiming she'd been physically injured by Tom during an argument at their apartment. (January 24, 1997)
- Gained 44 lbs. to portray John Gotti in Witness to the Mob (1998) by gorging on ice cream, pizza, pasta with cream sauce, meatball sandwiches and drinking weight gainer shakes.
- Formerly engaged to Heidi Fleiss.
- On 9/9/2004, Tom was shot at while driving in his car in Los Angeles. There was a passenger in the car, both Tom and the passenger were unharmed.
- Has twin sons Jayden and Jagger born in July of 2005 with ex-girlfriend Janelle McIntire.
- Attended at Temple University of Philadelphia and majored in theater.
- Favorite movies are: Taxi Driver (1976), Close Encounters of the Third Kind (1977) and The Deer Hunter (1978).
- In 2013, he wrote a Hollywood memoir about his gritty past and path to redemption.
- Was in attendance at Chris Penn's funeral
- Tom feels that doing homework is critical in perfecting his roles. For his role in The Relic (1997), he met with curators and scientists to learn more about the research behind public museum exhibits.
- Tom's wish list of people to work with are: Quentin Tarantino, 'Stanley Kubrick', Jodie Foster, Jack Nicholson and Bernardo Bertolucci.
- Met his ex-wife, Maeve Quinlan, on the set of Natural Born Killers (1994). Maeve was working as an extra.
- His father, Thomas Edward Sizemore, Sr., now retired, was a lawyer and philosophy professor.
- Has played characters in seven movies who have died in shootouts: True Romance (1993), Enemy of the State (1998), Saving Private Ryan (1998), Heat (1995), Natural Born Killers (1994), Devil in a Blue Dress (1995) and Dreamcatcher (2003). If counting voice work, the number goes up to eight!: He did the voice of Sonny Forelli in Grand Theft Auto: Vice City (2002), who is killed in a gang shootout.
- He is training in Jiu Jitsu and weightlifting to stay in shape as of 2011.
- Credits his childhood for his passion for acting. He watched the tough guys take care of business and decided that those were the roles that he would play when he got older.
- Tom's favourite horror flick is Alien (1979).
- Attended Wayne State University in Detroit, Michigan and graduated in theater (acting).
- He had English, German, Scottish, French, Irish, around one eighth African-American, and distant Native American, ancestry. His maternal grandfather, Samuel Schannault, was born in Georgia, to a white father and a black mother.
- In 1986 moved to New York City to pursue an acting career.
- Is the lead singer for the Hollywood rock band Day 8, formed in 2002. The members are Rod Casho, Michael Taylor, Lester Mendoza, and Tyrone Tomke. They have recorded a 4 song EP.
- When Tom arrived at boot camp he weighed 190lbs, but the food was so awful, he left weighing 178lbs. His first consumption upon leaving was a diet coke.
- His brother Aaron Sizemore is a writer and lives in Detroit.
- As a teenager, Tom sang tenor in musicals staged by local theatre groups. He was annoyed at not being considered for the part of "Che", (Antonio Banderas landed the role), in Alan Parker's Evita (1996). He's about to start taking singing lessons again (2009).
- Starred in numerous regional and off-Broadway theatrical productions including Horton Foote's "The Land of the Astronauts" at the Ensemble Studio Theatre in New York.
- For Natural Born Killers (1994), Tom was dressed by Giorgio Armani.
- His younger brother is Paul Sizemore.
- His mother, Judith (Schannault), was a member of the city of Detroit ombudsman staff.
- Auditioned for a role in Sideways (2004).
- Despite prominent roles in Academy Award nominated/winning films, Sizemore's name was not included at the Oscar during the In Memoriam tribute after his passing.
- Frequently worked with the producer Ryan R. Johnson.
- Was considered for the role of Jack Horne in The Magnificent Seven.
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