- Mother, with David Carradine, of son Tom Carradine.
- Lived until late 2009 with her then partner, actor Naveen Andrews from the TV series Lost (2004) , who is 21 years her junior.
- She has one child, a son she named Free. He later changed his name to Tom. His father is David Carradine.
- Acted for several years as Barbara Seagull because of a seagull that was accidentally killed during the filming of "Last Summer." At the time, she said she felt she had absorbed the seagull's spirit.
- As of 2007, she is the only woman to be cast twice in a major role in a movie by Martin Scorsese. The two movies are The Last Temptation of Christ (1988) and Boxcar Bertha (1972).
- Her five favourite films of all time are The Wizard of Oz (1939), Bicycle Thieves (1948), Dr. Strangelove or: How I Learned to Stop Worrying and Love the Bomb (1964), Raging Bull (1980) and The Ballad of Narayama (1983).
- She gave the book of The Last Temptation of Christ (1988) to Martin Scorsese, while filming Boxcar Bertha (1972) with him.
- As of 2014, has appeared in three films which were nominated for the Best Picture Oscar: The Right Stuff (1983), Hannah and Her Sisters (1986) and Black Swan (2010).
- The first (and as of 2006 the only) performer to win back to back acting awards at the Cannes Film Festival.
- Was considered for the role of an dangerous obsessive woman in Fatal Attraction (1987). She had played a similar role in The Natural (1984), where she stalks and shoots the hero, who loves a good woman, played by Glenn Close, who ironically, beat out Hershey for the role in Fatal Attraction (1987) in an against-type casting that made her a household name.
- She has appeared in two films selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: The Right Stuff (1983) and Hoosiers (1986).
- She shares a birthday with her sons grandfather John Carradine.
- Met ex-boyfriend Naveen Andrews on the set of Drowning on Dry Land (1999). They were together until late 2009, although they split for a brief time in 2005 during which Naveen fathered a child, Naveen Joshua.
- Barbara's father, Arnold Nathan Herzstein, was Ashkenazi Jewish. Barbara's paternal grandparents, Samuel Herzstein and Dora E. Sable, were from Shrepkow, Hungary and Russia, respectively. Barbara's mother, Melrose E. (Moore), who was originally from Arkansas, had English and Scots-Irish (Northern Irish) ancestry.
- Was considered to play as Catherine Tramell in Basic Instinct (1992) but turned it down.
- Member of the drill team and pom-pom squad in high school.
- Dated Warren Beatty.
- Daughter of Arnold Herzstein.
- She was born at 10:01 AM - PST.
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