- She turned down the role of Vin Diesel's love interest in the box-office hit The Pacifier (2005) to take a small but unforgettably sexy role in Sin City (2005) because she had enjoyed working with director Robert Rodriguez in the three "Spy Kids" films.
- Was her high school's valedictorian.
- Starred in two films in March 2009 that were back to back openings and USA box office kings. Watchmen (2009) opened March 6th, 2009, and was the number one film of the weekend. Race to Witch Mountain (2009) opened March 13th, 2009, and was the number one film of that weekend.
- Modeled for the prestigious Elite agency as a teenager but was considered too short for fashion runway work.
- Featured in the 1994 Bon Jovi music video, "Always", alongside Jack Noseworthy, Jason Wiles and Keri Russell.
- Is only seven years older than Malin Akerman, who played her daughter in Watchmen (2009).
- Had a kidney operation when she was only 4 years old.
- Grew up in Paradise, California.
- Was considered to play Velma Dinkley in Scooby-Doo (2002), but Linda Cardellini was cast instead.
- Her father was of Italian descent. Her mother's ancestry is English and Irish.
- Has a butterfly tattoo on the inside of her left ankle.
- Good friends with Elizabeth Berkley.
- Has a long scar on her left side (towards her back) from a a Kidney operation when she was 4 years old.
- Boyfriend is writer/director Sebastian Gutierrez, with whom she has worked on her TV series Karen Sisco (2003) and Rise: Blood Hunter (2007).
- Niece of actress Carol Merrill (Carol was married to Carla's uncle, Mark Burgess). Carol's daughter is actress Hillary Safire.
- Cousin of Hillary Safire.
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