- In 1983, Time magazine reported Rossellini's modeling salary of a then $9,000 a day.
- Dated Gary Oldman in the 1990s. He postponed their planned wedding in order to go to rehab for substance abuse. After meeting another woman in rehab, he called their engagement off.
- She suffered from scoliosis (progressive curvature of the spine) and underwent surgery to correct it. She was in a body cast for a year.
- Fluent in Italian, French and English.
- Considers her time with ex-boyfriend David Lynch as her "most significant relationship".
- Was engaged to director David Lynch from 1986 to 1990.
- Says her feminine style has been influenced by Georgia O'Keeffe and Jacqueline Kennedy (aka Jackie Kennedy Onassis).
- Is an avid dog lover and helps train puppies for the blind.
- Rossellini earned an MA in Animal Behavior & Conservation from Hunter College in New York in May of 2019.
- Virtually identical to her mother, Ingrid Bergman, but surprisingly had few opportunities to portray her mother in a biographical film. One occasion was an eerily accurate spoof of Ilsa Lund in an episode of Tales from the Crypt (1989). More recently, in the movie My Dad Is 100 Years Old (2005) for which she wrote the script, she did a moving portrayal of her mother.
- In the Tales from the Crypt (1989) episode, You, Murderer (1995), she spoofs her mother's Casablanca (1942) image.
- Appeared in photographs for Madonna's coffee table book "Sex".
- Her favorite Hollywood-film that her mother made is Notorious (1946). Her favorite films of her father, made without her mother, are The Taking of Power by Louis XIV (1966) and The Flowers of St. Francis (1950).
- Brother, Roberto Rossellini, was engaged to Princess Caroline of Monaco in the 1980s.
- Former model, most notably for Lancome, and former journalist for Italian television.
- She is 34 minutes older than twin sister Isotta.
- Is a huge fan of Buster Keaton and Charles Chaplin.
- Has worked to preserve the films of her parents through both archival work and biographical pieces.
- Discovered by photographer friend Bruce Weber who kick-started her modeling career.
- In 1991 she was scheduled to play Emilia Gould in David Lean's adaptation of the Joseph Conrad novel, Nostromo. Lean's death in April 1991 brought the production to an end.
- Her father was Italian, born in Rome, from a family originally from Tuscany and Veneto. Her mother, who was Swedish, was born in Stockholm, to a Swedish father and a German mother.
- Published an autobiography called "Some of me".
- Chosen by Empire magazine as one of the 100 Sexiest Stars in film history (#84) in 1995.
- Chosen by People magazine as one of the 50 Most Beautiful People in the world in 1990 and 1991.
- Will narrate Guy Maddin's silent film "Brand Upon the Brain" as part of the Winnipeg Symphony Orchestra's New Music Festival at the Winnipeg Centennial Concert Hall. (January 2008)
- Just finished another series of Green Porno short films for the Sundance Channel. (January 2009)
- Maintains a home in the village of Bellport, Long Island, New York.
- Isabella weighed 6 lbs 15 oz at birth according to the birth announcement published in the June 30th 1952 Milestones column of Time Magazine.
- Starring on Broadway in The Stendahl Syndrome. (February 2004)
- Her surname was originally Rosellini.
- President of the 'Official Competition' jury at the 61st Berlin International Film Festival in 2011.
- President of the 'Un Certain Regard' jury at the 68th Cannes International Film Festival in 2015.
- Winnipeg, Canada - filming Guy Maddin's The Saddest Music in the World (2003). (March 2003)
- She was a model mainly for the cosmetics firm Lancome for a number of years from the age of 28.
- Born at 6:07pm-CET.
- Born on the same day as actress Carol Kane.
- Did make up commercials.
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