- Dated actor Paul Reubens, best-known for his portrayal of "Pee-Wee Herman", from 1993-1999. Reubens credits her for ending the depression resulting from his scandalous 1991 arrest.
- Worked as a makeup artist for Madonna.
- Speaks fluent Italian.
- Was a hip-hop breakdancer in the early 1980s as evidenced in Graffiti Rock (1984).
- Close friend of Madonna.
- Her father, Harry Mazar, was born in Latvia, and was of Jewish heritage.
- Before she became a star, she was a beautician.
- On Round Three: Results Show (2009), she cleared up the pronunciation of her last name. She said her last name is really pronounced MaH-zahr, and not the commonly mispronounced May-zahr. However, she has accepted the media mispronouncing it as May-zahr.
- Did Madonna's make-up for the 1988 Broadway production of "Speed-the-Plow", which inspired her to take acting lessons.
- Grew up on Manhattan's Lower East Side.
- Famous for hosting parties.
- Mother, with husband Gabriele Corcos, of daughters Evelena Corcos (Evelyn Maria Corcos; b. July 12, 2002) and Giulia Corcos (Giulia Isabel Mazar-Corcos; March 17, 2006).
- Her character, Denise Iannello from Civil Wars (1991) was saved from the cancellation of that series and added to L.A. Law (1986) the following season.
- Sometimes confused with Fran Drescher due to her similar features and thick New York accent and has worked with her.
- Mazar played Jennifer Jenson, the boss whom Ali Larter was impersonating in House on Haunted Hill (1999). The director wanted her in the movie, but even after a reshoot, it was decided that her introductory scene slowed down the movie too much, so her closing scene also had to be cut. All of her scenes were included as DVD/blu-ray extras.
- She has appeared in two films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: Goodfellas (1990) and Malcolm X (1992).
- She holds the distinction of having appeared in one film each in the "Batman", "Casper", "Beethoven" and "Home Alone" film franchises.
- Sister-in-law of Fabio Corcos.
- She has worked with both of the main female stars of Cold Mountain (2003): Nicole Kidman in Batman Forever (1995) and Renée Zellweger in Empire Records (1995).
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