- In a 1988 Premiere magazine article, Matthew talked about his love scene with his Torch Song Trilogy (1988) co-star Brian Kerwin. He said, "It was fun being romantic, sexy with a man.".
- Before I knew it, I was like this guy in a hot play [Torch Song Trilogy]. And suddenly all these doors opened... It's just amazing. All these things have to line up that are out of your control.
- I acquired fame by playing the coolest kid who ever lived. Now, the only roles I can seem to get are bleak, insecure men. I do find almost every character I play quite interesting, though.
- [on his car crash] I don't remember the day. I don't remember even getting up in the morning. I don't remember making my bed. What I first remember is waking up in the hospital, with a very strange feeling going on in my leg.
- [2008] [5-year-old son James is] already curious. I can just see the little budding gene of a smoker in there. He'll see a cigarette butt and say, 'What is that? Why do people smoke?' I used to smoke cigarettes, and I still do, lately. I gave that up a long time ago, but every now and then I will fall off for a week. [Wife Sarah Jessica Parker is] worse than me on that.
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