Protein Science
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Recent papers in Protein Science
BACKGROUNDProstate cancer (PCa) is the second leading cause of cancer-related death in men in the United States. Many men have implemented purported chemopreventive agents into their daily diet in an attempt to delay the early onset of a... more
Calculating protein–protein interaction energies is crucial for understanding protein–protein associations. On the basis of the methodology of mean-field potential, we have developed an empirical approach to estimate binding free energy... more
Penicillin G acylase (PGA) is a heterodimeric enzyme synthesized as a single-polypeptide precursor that undergoes an autocatalytic processing to remove an internal spacer peptide to produce the active enzyme. We constructed a single-chain... more
We present a study of the competition between protein refolding and aggregation for simple lattice model proteins. The effect of solvent conditions (i.e., the denaturant concentration and the protein concentration) on the folding and... more
The complement inhibitors C4b-binding protein (C4BP) and factor H (FH) both consist of complement control protein (CCP) domains. Here we examined the secondary structure of both proteins by circular dichroism and Fourier-transform... more
The native conformation of host-encoded cellular prion protein (PrP C ) is metastable. As a result of a post-translational event, PrP C can convert to the scrapie form (PrP Sc ), which emerges as the essential constituent of infectious... more
The C-terminal oligomerization domain of chicken cartilage matrix protein is a trimeric coiled coil comprised of three identical 43-residue chains. NMR spectra of the protein show equivalent magnetic environments for each monomer,... more
The heat capacity plays a ma- jor role in the determination of the energetics of protein folding and molecular recognition. As such, a better understanding of this thermody- namic parameter and its structural origin ...
The X-ray structure of an oxygenated hemocyanin molecule, subunit I1 of Limulus polyphemus hemocyanin, was determined at 2.4 A resolution and refined to a crystallographic R-factor of 17.1%. The 73-kDa subunit crystallizes with the... more
BACKGROUNDProstate cancer has been reported to occur more commonly in neutered than intact male dogs in several case series. This study was undertaken to evaluate risk of prostate cancer in a large population database. The hypothesis was... more
Presentasi materi pembelajaran kimia kelas 3, Sekolah Menengah Kejuruan 1 Kota Cimahi, Jawa Barat.
Protein structure alignment methods are essential for many different challenges in protein science, such as the determination of relations between proteins in the fold space or the analysis and prediction of their biological function. A... more
The chapter gives more information about the application of integrated nutrigenomics approach in nutritional sciences. It also emphasized for accelerated implementation of mechanistic knowledge in food design. It gives an application and... more
An elementary introduction into the Seiberg-Witten theory is given. Many efforts are made to get it as pedagogical as possible, and within a reasonable size. The selection of the relevant material is heavily oriented towards graduate... more
The free radical-mediated damage to proteins results in the modification of amino acid residues, cross-linking of side chains and fragmentation. L-tyrosine and protein bound tyrosine are prone to attack by various mediators and reactive... more
The pressure dependence of the flexibility of the 8-anilino-1-naphthalene sulfonate (ANS)-apomyoglobin complex was investigated in the range between atmospheric pressure and 2.4 kbar by frequency domain fluorometry. We examined two... more
These lectures give an elementary introduction to the subject of four dimensional black holes (BHs) in supergravity and the Attractor Mechanism in the extremal case. Some thermodynamical properties are discussed and some relevant formulae... more
In solution, the oxygen affinity of hemoglobin in the T quaternary structure is decreased in the presence of allosteric effectors such as protons and organic phosphates. To explain these effects, as well as the absence of the Bohr effect... more
The mineral element content of coconut water from three (3) different species was determined in samples gotten form Rivers State. Ca, Na, K, Fe, Cu, S, P and Cl were determined using the Atomic Absorption... more
The proximate composition of Bryophyllum pinnatum leaves was evaluated in both dry and fresh samples to determine the ash, carbohydrate, fat, fibre, protein, moisture and mineral contents using the method of Association of Analytical... more
The key to the keys to immortality and eternal youth lies in the correct answer to the main question: How to naively discover new essential – but still hidden – features required for properly training novel adaptive supervised machine... more
A rare γ-pyranopyrazole skeleton: design, one-pot synthesis and computational study † Drawing upon a consecutive amide coupling and intramolecular cyclisation pathway, a one-pot, straightforward synthetic route has been developed for a... more
DsbA is the strongest protein disulfide oxidant yet known and is involved in catalyzing protein folding in the bacterial periplasm. Its strong oxidizing power has been attributed to the lowered pK, of its reactive active site cysteine and... more
B-cell epitopes play a vital role in the development of peptide vaccines, in diagnosis of diseases, and also for allergy research. Experimental methods used for characterizing epitopes are time consuming and demand large resources. The... more
Because Tyr35 is located at the convergence of the ␣11, ␣12, and ␣1␣2 interfaces in deoxyhemoglobin, it can be argued that mutations at this position may result in large changes in the functional properties of hemoglobin. However, only... more
Abbreviations: CEP, palm tree -Chamaerops excelsa -peroxidase; CD, circular dichroism; DSC, differential scanning calorimetry. * Corresponding authors.
A two-component recombinant fusion protein antigen was re-engineered and tested as a medical counter measure against the possible biological threat of aerosolized Yersinia pestis. The active component of the proposed subunit vaccine... more
The fourth EGF-like domain of thrombomodulin (TM4), residues E346-F389 in the TM sequence, has been synthesized. Refolding of the synthetic product under redox conditions gave a single major product. The disulfide bonding pattern of the... more
In this study, the chemical composition of 32 samples coming from 29 different biomass species including a gymnosperm, 2 dicotyledonous angiosperms, 17 monocotyledonous angiosperms and 9 algae species was successfully determined using an... more
In the last decade enormous advances in life sciences have been possible due to the information obtained from DNA sequencing projects. The optimal interpretation and analysis of genome sequence data requires the precise annotation and... more
Hydropathy plot methods form a cornerstone of membrane protein research, especially in the early stages of biochemical and structural characterization. Membrane Protein Explorer (MPEx), described in this article, is a refined and... more
The production of recombinant proteins in bacteria has increased significantly in recent years, becoming a common tool for both research and the industrial production of proteins. One of the requirements of this methodology is to obtain... more
BACKGROUNDProstate cancer (PCa) is the second leading cause of cancer-related death in men in the United States. Many men have implemented purported chemopreventive agents into their daily diet in an attempt to delay the early onset of a... more
Techniques from graph theory are applied to analyze the bond networks in proteins and identify the flexible and rigid regions. The bond network consists of distance constraints defined by the covalent and hydrogen bonds and salt bridges... more