Longevity

Objectives: To delineate the influences of the Mediterranean diet (MD) on human mortality and agerelated morbid conditions, principally the metabolic syndrome, hypertension, cardiovascular disease, excess body weight, cancer, poor bone mineralization and rheumatoid arthritis, and neurodegenerative disorders. Method: Citations were selected from a PubMed search according to their clinical and experimental relevance. Results and conclusions: Individuals who adhere to the principles of the traditional MD tend to have a longer life-span. Both men and women who report eating foods closest to the MD are about 10-20% less likely to die over the course of a study of heart disease, cancer or any other cause. The longevity of Mediterranean people has been related to olive oil, and its several microcomponents of antioxidant potential, present in all MD variants. The prevalence of the metabolic syndrome may be reduced by a MD. The MD is significantly inversely associated with both systolic and diastolic blood pressure. It also has benefits in relation to the prevention of cardiovascular events, reduces the risk of mortality after myocardial infarction, and reduces peripheral arterial disease. The risk of obesity decreases with increasing adherence to the traditional MD. The MD also has a preventive effect on cancer, through its antiproliferative and proapoptotic effects, mostly due to the components of virgin olive oil and vegetables. There is some evidence of the benefits of the MD in relation to bone metabolism, rheumatoid arthritis, and neurodegenerative age-related diseases (cognitive deficit, Alzheimer's disease, Parkinson's disease).

This article introduces how one can design for product longevity through eliciting consumer-product attachment in order to restrain the rate of product replacement. The research disclosed the design tool ”Contexts of Experience” (COE) which combines strategies of consumer–product attachment and associated psychological phenomenon. The COE was disclosed and analyzed through case study.

An expression of art or craft diminishes with changing philosophy over time, but an architectural expression tends to remain. The built form eventually becomes one of the very few representations of previous civilizations that have stood the test of time. Centuries old buildings have lasted, although they were not specifically designed for timelessness. The act of building is not a temporal one, each one is a representation of its time. The quality of remaining unchanged indefinitely or permanence in architecture can be achieved with the use of enduring construction material and sympathetic regard for the surroundings. Buildings outlive generations and as such need to be resourcefully designed to continue to be effective. A conscious use of the local materials, the local technical skills has allowed these buildings to harmonize with the context. Born of the earth, each of these speaks the language of the people and of the place. On the contrary, in Indian urban centers, a large quantum of the architectural expression today is ignorant of its place and time. There is a diminishing reverence to what the place demands and more attention to what we demand of it. This paper explores the connections between a building's context and time to its longevity. It argues that concentrated efforts made towards rootedness to a place and relevance to its time, will lead to significantly bolstering a building's perseverance. It also enquires into longevity through examples spanning different contexts and times. Significant examples of historic buildings of a place are discussed in comparison with contemporary examples of similar locations. Such a comparison will lead to an understanding of ways of adapting traditional knowledge to current needs and their appropriation to the time. The paper seeks to emphasize the importance of contextuality and close connect to time, in extending the life of a building.

Growth rates and longevities were estimated for five major fishery species of parrotfishes (“uhu”) at Oahu, Hawai’i. All species grew rapidly with von Bertalanffy growth formula k values ≥0.4·year−1. Longevities were found to range broadly among the three small species, 4 years in Calotomus carolinus and 6 and 11 years in Scarus psittacus and Chlorurus spilurus, and to 15–20 years in Scarus rubroviolaceus and Chlorurus perspicillatus for the two large species. Age reading and growth curves for the latter two large species were validated using bomb radiocarbon dating. Median ages at sexual maturity as females (AM50) and at sex change (from female to terminal phase male, AΔ50) were estimated using logistic models. Sexual maturation occurred at 1–2 years for the small species and at 3–3.5 years in the large species. AΔ50 estimates ranged from 2 to 4 years in the small species and were about 5 and 7 years in S. rubroviolaceus and C. perspicillatus, respectively. Estimated milestones poo...

Senescence arises from age-specific deterioration of the soma as a consequence of optimization of life history, and such effects of senescence should appear when comparing species that differ in intensity of sexual selection, as well as when comparing, within a species, the two sexes that often differ in intensity of sexual selection. However, any extrinsic cause of mortality that reduces life expectancy will reduce the possibility of detecting sex-specific differences in senescence. We investigated geographical variation in human sex differences in longevity across 121 countries to test whether differences in sexual competition for limiting resources, reflecting intensity of sexual selection, affected sex differences in longevity. Men on average lived 5 years shorter than women. High rates of childhood morbidity and mortality reduced the sex difference in longevity, while increased overall longevity increased the sex difference in longevity. Increased resource availability estimated from gross domestic product per capita reduced the sex difference in longevity, accounting for 10% of the variance, while there was no additional effect of income inequality as reflected by the Gini coefficient. In a separate analysis of sex differences in longevity among the states of the US, there was a strong effect of the Gini coefficient on sex difference in longevity, with the negative effect on male longevity being stronger than that on female longevity. In contrast, there was only a marginal effect of average household income. Thus, there was evidence of increased competition for resources contributing to increased sex differences in longevity within a single nation. Am. J. Hum. Biol., 2009. © 2009 Wiley-Liss, Inc.

Untreated cystathionine ␤-synthase (CBS) deficiency in humans is characterized by extremely elevated plasma total homocysteine (tHcy>200 M), with thrombosis as the major cause of morbidity. Treatment with vitamins and diet leads to a dramatic reduction in thrombotic events, even though patients often still have severe elevations in tHcy (>80 M). To understand the difference between extreme and severe hyperhomocysteinemia, we have examined two mouse models of CBS deficiency: Tg-hCBS Cbs Ϫ/Ϫ mice, with a mean serum tHcy of 169 M, and Tg-I278T Cbs Ϫ/Ϫ mice, with a mean tHcy of 296 M. Only Tg-I278T Cbs Ϫ/Ϫ animals exhibited strong biological phenotypes, including facial alopecia, osteoporosis, endoplasmic reticulum (ER) stress in the liver and kidney, and a 20% reduction in mean survival time. Metabolic profiling of serum and liver reveals that Tg-I278T Cbs Ϫ/Ϫ mice have significantly elevated levels of free oxidized homocysteine but not protein-bound homocysteine in serum and elevation of all forms of homocysteine and S-adenosylhomocysteine in the liver compared to Tg-hCBS Cbs Ϫ/Ϫ mice. RNA profiling of livers indicate that Tg-I278T Cbs Ϫ/Ϫ and Tg-hCBS Cbs Ϫ/Ϫ mice have unique gene signatures, with minimal overlap. Our results indicate that there is a clear pathogenic threshold effect for tHcy and bring into question the idea that mild elevations in tHcy are directly pathogenic. Mouse models of cystathionine ␤-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia. FASEB J. 23, 883-893 (2009) Key Words: osteoporosis ⅐ ER stress ⅐ inborn error of metabolism ⅐ sulfur metabolism Cystathionine ␤-synthase (CBS) deficiency is the most common inborn error of sulfur metabolism and is the cause of classical homocystinuria, a condition char-

Objective: To test whether cholesterol ester transfer protein (CETP) genotype (VV homozygosity for I405V) is associated with preservation of cognitive function in addition to its association with exceptional longevity. Methods: We studied Ashkenazi Jews with exceptional longevity (n ϭ 158; age 99.2 Ϯ 0.3 years) for the associations of CETP VV genotype and lipoprotein phenotype, using the Mini-Mental State Examination (MMSE). To confirm the role of CETP in a younger cohort, we studied subjects from the Einstein Aging Study (EAS) for associations between CETP VV and cognitive impairment. Results: Subjects with MMSE Ͼ 25 were twice as likely to have the CETP VV genotype (29% vs 14%, p ϭ 0.02), and those with the VV genotype were more likely (61% vs 30%, p ϭ 0.02) to have MMSE Ͼ 25. Subjects with the VV genotype had lower levels of CETP (1.73 Ϯ 0.11 vs 2.12 Ϯ 0.10 g/mL, p ϭ 0.01), higher high-density lipoprotein (HDL) levels (p ϭ 0.02), and larger lipoprotein particles (p ϭ 0.03). In the EAS cohort, an approximately fivefold increase in the VV genotype (21% vs 4%, p ϭ 0.02), higher HDL levels, and larger lipoprotein particle sizes were associated with less dementia and improved memory. Conclusions: Using two independent cohorts, we implicate the longevity CETP gene as a modulator of age-related cognitive function. A specific CETP genotype is associated with lower CETP levels and a favorable lipoprotein profile. It has not been determined whether modulation of this gene prevents age-related decline or AD.

Beverages sweetened with caloric sweeteners (CS), glucose, sucrose or high-fructose corn syrup, are associated with weight gain. Beverages sweetened with intense sweeteners (IS) are marketed as low-calorie substitutes to prevent beverages-associated weight gain. Using Caenorhabditis elegans, the effects on intestinal fat deposition (IFD) and pharyngeal pumping rate (PPR) of cola beverages sweetened with glucose, aspartame, or aspartame plus acesulfame-potassium (AceK) were compared. Control groups received Escherichia coli (OP50) only. Study I: the nematodes received additional glucose-or IS-sweetened beverages. Study II: the nematodes received additional glucose, aspartame, or aspartame plus AceK (AAK). Beverages containing CS or IS (aspartame or AAK) did not alter IFD in wild type (N2) or in daf-16 deficiency. The CS cola increased IFD in sir-2.1 deficiency (P < 0.05). The AAK-cola increased IFD in daf-16/daf-2 deficiency and sir-2.1 deficiency (P < 0.05). Glucose increased IFD in N2 and daf-16 deficiency (P < 0.05). Aspartame showed a tendency towards reduced IFD in N2 and decreased IFD in daf-16/daf-2 deficiency (P < 0.05). AAK increased IFD in daf-16 deficiency and sir-2.1 deficiency (P < 0.05), and reversed the aspartame-induced reduction in IFD. The aspartame-sweetened cola increased the PPR in daf-16/daf-2 deficiency and daf-16 deficiency (P < 0.05); similar results were obtained in N2 with both IS (P < 0.05). AAK increased the PPR in daf-16/daf-2, daf-16, and sir-2.1 deficiencies (P < 0.05). Thus, IS increased the PPR, a surrogate marker of lifespan. Aspartame may have an independent effect in reducing IFD to assist humans desiring weight loss. AceK may increase IFD in presence of insulin resistance.

Restricting caloric intake to 60-70% of normal adult weight maintenance requirement prolongs lifespan 30-50% and confers near perfect health across a broad range of species. Every other day feeding produces similar effects in rodents, and profound beneficial physiologic changes have been demonstrated in the absence of weight loss in ob/ob mice. Since May 2003 we have experimented with alternate day calorie restriction, one day consuming 20-50% of estimated daily caloric requirement and the next day ad lib eating, and have observed health benefits starting in as little as two weeks, in insulin resistance, asthma, seasonal allergies, infectious diseases of viral, bacterial and fungal origin (viral URI, recurrent bacterial tonsillitis, chronic sinusitis, periodontal disease), autoimmune disorder (rheumatoid arthritis), osteoarthritis, symptoms due to CNS inflammatory lesions (Tourette's, Meniere's) cardiac arrhythmias (PVCs, atrial fibrillation), menopause related hot flashes. We hypothesize that other many conditions would be delayed, prevented or improved, including Alzheimer's, Parkinson's, multiple sclerosis, brain injury due to thrombotic stroke atherosclerosis, NIDDM, congestive heart failure.

Variation in human lifespan is 20 to 30% heritable but few genetic variants have been identified. We undertook a Genome Wide Association Study (GWAS) using age at death of parents of middle-aged UK Biobank participants of European decent (n=75,244 with father&#39;s and/or mother&#39;s data). Genetic risk scores for 19 phenotypes (n=777 proven variants) were also tested. Genotyped variants (n=845,997) explained 10.2% (SD=1.3%) of combined parental longevity. In GWAS, a locus in the nicotine receptor CHRNA3 - previously associated with increased smoking and lung cancer - was associated with paternal age at death, with each protective allele (rs1051730[G]) being associated with 0.03 years later age at father&#39;s death (p=3x10-8). Offspring of longer lived parents had more protective alleles (lower genetic risk scores) for coronary artery disease, systolic blood pressure, body mass index, cholesterol and triglyceride levels, type-1 diabetes, inflammatory bowel disease and Alzheimer&#3...

■ Abstract Personality has consequences. Measures of personality have contemporaneous and predictive relations to a variety of important outcomes. Using the Big Five factors as heuristics for organizing the research literature, numerous consequential relations are identified. Personality dispositions are associated with happiness, physical and psychological health, spirituality, and identity at an individual level; associated with the quality of relationships with peers, family, and romantic others at an interpersonal level; and associated with occupational choice, satisfaction, and performance, as well as community involvement, criminal activity, and political ideology at a social institutional level.

Optimising the number of replacement heifers needed will have positive economic and environmental consequences on herds that rear their own young stock. The number of heifers needed to be kept is closely related with the number of culled dairy cows in the herd. This study therefore looked at the variation that exists in culling rate and herd level factors associated with it. A dataset from 1903 dairy herds available included information at animal level (dates of culling, slaughter/death) and herd level (characteristics of reproduction, performance, health) over the years 2007 to 2010. The average culling rate for slaughter/death was used and was defined for each year as percentage of the herd size that died within 30 d after they were culled. The analysis of the association between average culling rate for slaughter/death and the characteristics of the herd was performed using a mixed model. The results showed that the average culling rate for slaughter/death was 25·4% and varied be...

Das Design wird gerne als Paradebeispiel einer Gestaltung aufgefasst, die transformierend in natürliche wie soziale Wirklichkeiten eingreift, eine unmittelbare Umgestaltung der Wirklichkeit leistet, während künstlerischen Praktiken gerne – gerade in Entgegensetzung zum Design – eine vermitteltes Reflexionsverhältnis zur Wirklichkeit attestiert wird und weniger ein wirklichkeitsveränderndes Verhältnis. Ich versuchen zu zeigen, dass dem Design neben dieser transformierenden Seite auch eine Wirklichkeit reflektierende Seite zukommt und wie diese beiden Dimensionen des Designs zusammenhängen. Hierzu konzentriere ich mich auf Formen des Designs, die sich gegenwärtig durch die Betrachtung der Dinge nach ökologischen Gesichtspunkten entwickeln. Vor diesem Hintergrund mache ich schließlich einen kurzen Vorschlag, wie dieses Designverständnis auch für das Verständnis der Kunst fruchtbar gemacht werden kann.

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The mechanisms that concern DNA repair have been studied in the last years due to their consequences in cellular homeostasis. The diverse and damaging stimuli that affect DNA integrity, such as changes in the genetic sequence and modifications in gene expression, can disrupt the steady state of the cell and have serious repercussions to pathways that regulate apoptosis, senescence, and cancer. These altered pathways not only modify cellular and organism longevity, but quality of life ("health-span"). The DNA mismatch repair system (MMR) is highly conserved between species; its role is paramount in the preservation of DNA integrity, placing it as a necessary focal point in the study of pathways that prolong lifespan, aging, and disease. Here, we review different insights concerning the malfunction or absence of the DNA-MMR and its impact on cellular homeostasis. In particular, we will focus on DNA-MMR mechanisms regulated by known repair proteins MSH2, MSH6, PMS2, and MHL1, among others.

Background and aim Angiotensin II acts through two major receptors: AT1-R and AT2-R. It is known that the stimulation of AT1-R mediates vasoconstriction, cell proliferation and fibrosis, aldosterone release and inflammatory response but, although the stimulation of AT2-R is thought to promote vasodilation and antiinflammatory effects, its real in-vivo functions are still unclear. The aim of this study was to investigate the effects of specific and selective AT2-R stimulation on the pathological events occurring in spontaneously hypertensive stroke-prone rats (SHRSPs).

In searching for different patterns of practice, lifestyle, and environment supportive of optimal health, we look to our elders around the world, who in the wisdom that has sustained them, we learn from with careful attention. Thirty-seven elders who live by their traditions participated in the present study. They assisted in the refinement of the methodology and collections and preparation of these data. These participants are well-respected, representative elders and traditional healers of their regions. These data, from study sites of the Eastern Afromontane and Albertine Rift region of Ethiopia, Africa; the Maya Mountains region of Belize, Central America; the Western Ghats region of India; and the Appalachian Mountains region of the United States, were grouped into three major categories: (1) philosophy, attitudes, and outlook, (2) lifestyle practices, and (3) dietary and nutritional practices. These elders demonstrate a relatively comprehensive but simple set of practices that can enhance our vitality and promote longevity sustainably. In essence, these practices, or practice wisdom, of our longest living elders, promote propagation of healthful lifestyles by following traditional ways and taking care of body, mind, spirit and our environment. Further field research among a larger cohort is required to fully generalize the findings of this study, but much of it is consistent with what we already know should be done. These data begin illustration of practice wisdom for implementation and serve to engage our universities, our hospitals, our industries, and our students, who we must position toward social change.

Mortality forecasting became a big challenge not only for demographers but also for actuaries. Different models were proposed for this issue while insuring effciency and simplicity. These models have been based on time and age dimensions. The analysis of mortality reductions schemes by age shows some inequalities related to age. Generally, the difference is well apparent between lower and higher ages. This can&#39;t be only tied to time, but also to the year of birth. Considering the cohort effect in morality forecasting has to improve the fitting quality. In the present paper, we propose to forecast the age-specific mortality rates in Algeria with considering cohort effect by comparison a set of models.

Much of contemporary research in Artificial Immune Systems (AIS) has partitioned into either algorithmic machine learning and optimisation, or modelling biologically plausible dynamical systems, with little overlap between. Although the balance is latterly beginning to be redressed (e.g.

Centenarians represent a group of population displaying the most rapid expansion. This progressive increase of the presence of centenarians is a multi-factorial phenomenon, which is due to the improvements of the environmental conditions and the life style and also to the progress of the medical science. In order to obtain a more reliable estimate of the longevity per gender and territorial entities, we propose two new indicators. (i) The ratio between the ultranonagenarians and the total population above 65 years old (called longevity index: LI%); (ii) the ratio between the centenarians and the total population above 90 years old (called centenarity index: CI%). An analysis of the data of the Italian National Office of Statistics (ISTAT, www.istat.it/Popolazione/Demo) using these two indicators demonstrates that the subjects above the age of 90 are more frequent in the regions of Central and Northern Italy, which are more developed regarding the economic conditions and technological progress. Nevertheless, the Southern and Insular regions of Italy have a higher occurrence of centenarians among the ultranonagenarian population, and also a higher prevalence of male centenarians, as compared to the northern regions. This demonstrates that achievement of the threshold of 100 years old does not require only particular socio-economic conditions, but also an adequate climate and environment, as well as a favorable genetic composition. #

1. On a private property with a stable population of wild red-legged partridge (Alectoris rufa) and an appropriate habitat for the survival of the species, reinforcement repopulations were carried out in the months of October and November for two consecutive years using 5-to 6-month-old birds reared on a commercial game farm. 2. Of the 36 released birds, none was still alive by the following spring's breeding period. Mean survival time was 9 . 4 d in the first year and 7 . 6 d in the second year. 3. Seventy-two per cent of mortality was attributable to predation, 11% to hunting and 17% to doubtful causes of death, accidents and starvation. 4. Post-release mean dispersion was 377 . 8 m in the first year and 526 . 3 m in the second. Mean home range was 7 . 1 ha in the first year and 5 . 4 ha in the second. 5. The production systems and handling practices of commercial game farms may have modified some anti-predator ethological patterns and strategies, which might make it more difficult for the birds to adapt and integrate into the wild, resulting in reduced survival due to premature mortality.

Labisia pumila (Myrsinaceae), is a popular herb among the women in Malaysia known locally as ''Kacip Fatimah". Recently many nutraceutical products containing the powdered or extracted parts of the plant have become available for women's health care. However no evaluation of the effect of the repeated dosing of any herbal product of this plant had been undertaken prior to a 28-day sub-acute study presented in this report. The results showed that a dose of 50 mg/kg of an aqueous extract of L. pumila corresponded to no-adverse-effect-level (NOAEL), whereas higher doses were associated with some toxicity concerns.

This paper will focus on the rationale of using Growth Hormone (GH) as an anti-ageing therapy in the healthy elderly with age-related decline in the activity of the GH/IGF-I axis, the so called &quot;somatopause&quot;. Although the age-related decline in the activity of the GH/IGF-I axis is considered to contribute to age-related changes similar to those observed in Growth Hormone Deficient (GHD) adults, GH/IGF-I deficiency or resistance is also known to result in prolonged life expectancy, at least in animals. These data raise the question whether or not GH deficiency constitutes a beneficial adaptation to ageing and therefore requires no therapy. Moreover, although GH therapy has been shown to exert positive effects in GHD patients, its safety, efficacy and role in healthy elderly individuals is highly controversial. This review provides a comprehensive account of the implications of GH therapy in the ageing subject.

Health care economic analyses are becoming increasingly important in the evaluation of health care interventions, including many within ophthalmology. Encompassed with the realm of health care economic studies are cost-benefit analysis, cost-effectiveness analysis, cost-minimization analysis, and cost-utility analysis. Cost-utility analysis is the most sophisticated form of economic analysis and typically incorporates utility values. Utility values measure the preference for a health state and range from 0.0 (death) to 1.0 (perfect health). When the change in utility measures conferred by a health care intervention is multiplied by the duration of the benefit, the number of quality-adjusted life-years (QALYs) gained from the intervention is ascertained. This methodology incorporates both the improvement in quality of life and/or length of life, or the value, occurring as a result of the intervention. This improvement in value can then be amalgamated with discounted costs to yield ex...

Bilirubin is a potent antioxidant and an important anti-inflammatory factor. Therefore, there has been an increasing focus on serum bilirubin as a negative risk factor of cardiovascular mortality in men and an indicator of improved survival in both sexes, but the direct mechanisms of these links and the causes of sex differences are not well understood. Moreover, the evidence from longitudinal studies on effects of bilirubin on longevity is limited. In this study, we retrospectively analyzed two groups of older adults to explore age-dependent changes in serum bilirubin levels and their associations with long-term survival in both sexes. Longitudinal data from 142 individuals (68 men and 74 women) aged 45 to 70 years were compared with cross-sectional data from 225 individuals (113 men and 112 women). The latter group was divided into four categories of survival, i.e. 53, 63, 68, and 76+ based on data on lifespan. ANOVA, t-test, and regression analysis were run. The analysis of the l...

The vulnerability of the nervous system to advancing age is all too often manifest in neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. In this review article we describe evidence suggesting that two dietary interventions, caloric restriction (CR) and intermittent fasting (IF), can prolong the health-span of the nervous system by impinging upon fundamental metabolic and cellular signaling pathways that regulate lifespan. CR and IF affect energy and oxygen radical metabolism, and cellular stress response systems, in ways that protect neurons against genetic and environmental factors to which they would otherwise succumb during aging. There are multiple interactive pathways and molecular mechanisms by which CR and IF benefit neurons including those involving insulin-like signaling, FoxO transcription factors, sirtuins and peroxisome proliferatoractivated receptors. These pathways stimulate the production of protein chaperones, neurotrophic factors and antioxidant enzymes, all of which help cells cope with stress and resist disease. A better understanding of the impact of CR and IF on the aging nervous system will likely lead to novel approaches for preventing and treating neurodegenerative disorders.

The increased longevity in modern societies raised the attention to biological interventions that could promote a healthy aging. Mitochondria are main organelles involved in the production of adenosine triphosphate (ATP), the energetic substrate for cellular biochemical reactions. The production of ATP occurs through the oxidative phosphorylation of intermediate substrates derived from the breakdown of lipids, sugars, and proteins. This process is coupled to production of oxygen reactive species (ROS) that in excess will have a deleterious role in cellular function. The damage promoted by ROS has been emphasized as one of the main processes involved in senescence. In the last decades, the discovery of specialized proteins in the mitochondrial inner membrane that promote the uncoupling of proton flux (named uncoupling proteins-UCPs) from the ATP synthase shed light on possible mechanisms implicated in the buffering of ROS and consequently in the process of aging. UCPs are responsible...

"La convergence des progrès récents de la biologie, de la médecine et de la technologie permet de rendre possible aujourd’hui ce qui était encore impensable hier : modifier voire retarder de nombreuses manifestations du vieillissement.
Grâce à ces innovations, nous pouvons maintenant régénérer les cellules, restaurer les fonctions, rajeunir le look, maintenir les performances physiques et intellectuelles, anticiper les maladies, traiter et même guérir celles réputées incurables, etc.
Ce guide complet fait le tour des armes anti-âge actuelles : cellules souches et thérapie cellulaire, thérapies génétiques, hormones de croissance, interventions pharmacologiques, implants bioniques, médecine et chirurgie esthétiques, nutrition anti-âge et thérapeutique, etc. Un ouvrage de référence, rédigé par une spécialiste du vieillissement et fondé sur des faits scientifiques et des résultats d’études d’experts internationaux."

Motor behavior is modulated by dopamine-responsive neurons in the striatum, where dopaminergic signaling uses G-protein-coupled pathways, including those that result in the activation of cAMP-dependent protein kinase (PKA). The RIIbeta isoform of PKA is highly enriched in the striatum, and targeted disruption of the RIIbeta gene in mice leads to a dramatic reduction in total PKA activity in this region. Although the mutant mice show typical locomotor responses after acute administration of dopaminergic drugs, they display abnormalities in two experience-dependent locomotor behaviors: training on the rotarod task and locomotor sensitization to amphetamine. In addition, amphetamine induction of fos is absent, and the basal expression of dynorphin mRNA is reduced in the striatum. These results demonstrate that motor learning and the regulation of neuronal gene expression require RIIbeta PKA, whereas the acute locomotor effects of dopaminergic drugs are relatively unaffected by this PKA...

The oxidative stress theory of aging predicts that manipulations that alter oxidative stress/damage will alter aging. The gold standard for determining whether aging is altered is life span, i.e., does altering oxidative stress/damage change life span? Mice with genetic manipulations in their antioxidant defense system designed to directly address this prediction have, with few exceptions, shown no change in life span. However, when these transgenic/knockout mice are tested using models that develop various types of agerelated pathology, they show alterations in progression and/or severity of pathology as predicted by the oxidative stress theory: increased oxidative stress accelerates pathology and reduced oxidative stress retards pathology. These contradictory observations might mean that (a) oxidative stress plays a very limited, if any, role in aging but a major role in health span and/or (b) the role that oxidative stress plays in aging depends on environment. In environments with minimal stress, as expected under optimal husbandry, oxidative damage plays little role in aging. However, under chronic stress, including pathological phenotypes that diminish optimal health, oxidative stress/damage plays a major role in aging. Under these conditions, enhanced antioxidant defenses exert an "antiaging" action, leading to changes in life span, age-related pathology, and physiological function as predicted by the oxidative stress theory of aging.

A mark-release-recapture experiment with the progeny of wild collected Culex tritaeniorhynchus was conducted at the village of Khokhar near Lahore, Pakistan, during June-July 1976, the onset of the monsoon. Recapture rates for each of three releases ranged from a low of 0*19",, for males to a high of 0.58",, for females.