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Empathy for another's physical pain has been demonstrated in humans [1] and mice ; in both species, empathy is stronger between familiars. Stress levels in stranger dyads are higher than in cagemate dyads or isolated mice , suggesting... more
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      Empathy (Psychology)PainStressHumanized mouse models
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      Immune responseClinical TrialCancer ImmunotherapyHumanized mouse models
Klebsiella pneumoniae is a bacterial pathogen of worldwide importance and a significant contributor to multiple disease presentations associated with both nosocomial and community acquired disease. ATCC 43816 is a well-studied K.... more
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      GenomicsMacrophagesMultidisciplinaryNext generation sequencing
Se ha evaluado los probables efectos tóxicos del extracto acuoso de Picrosia longifolia Don "Achicoria" sobre el desarrollo de embriones preimplantacionales de ratón. Extracto acuoso de P. longifolia al 20%, 10% y 0% fue suministrado a... more
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      PeruHumanized mouse modelsEmbryotoxicologyAqueous Extract
Noninvasive functional imaging holds great promise for serving as a translational bridge between human and animal models of various neurological and psychiatric disorders. However, despite a depth of knowledge of the cellular and... more
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      NeuroimagingHumanized mouse modelsFunctional ConnectivityConnectomics
Alzheimer’s disease (AD) researchers have struggled for decades to draw a causal link between extracellular Aβ aggregation and intraneuronal accumulation of microtubule-associated protein tau. The amyloid cascade hypothesis posits that Aβ... more
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      Alzheimer's DiseaseHumanized mouse modelsBeta AmyloidNeurofibrillary Tangles
UDP-Glucuronosyltransferases (UGTs) conjugate a glucuronyl group from glucuronic acid to a wide range of lipophilic substrates to form a hydrophilic glucuronide conjugate. The glucuronide generally has decreased bioactivity and increased... more
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      PharmacogenomicsDrug metabolismHumanized mouse models
This paper explores the development of a novel biomedical research organism, and its potential implications for the corporeal and experimental practices of translational medicine. The humanized mouse is a complex experimental object in... more
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      Human GeographySTS (Anthropology)Humanized mouse models
The use of medicinal plants for the treatment of illnesses is widely known. However, there are not many scientific reports about the properties of these plants and their side effects. In this study, the effect of the aqueous extract of... more
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      PeruMedicinal PlantsHumanized mouse modelsEmbryotoxicology
Tumor suppressor p53 plays an important role in regulating cell cycle progression and apoptosis. Here we applied RNA interference to study the role of p53 in human hematopoietic development in vivo. An siRNA construct specifically... more
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      ImmunologyBiotechnologyFlow CytometryGene Therapy
The toxic effects of aquous extract of Picrosia longifolia Don “achicoria” on preimplantational mouse embryo development were evaluated. Aquous extract of P. longifoliato 20%, 10% and 0% (control group) was supplied to pregnant mice to 86... more
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      PeruHumanized mouse modelsEmbryotoxicologyAqueous Extract
(2017): Neotomodon alstoni mice present sex differences between lean and obese in daily hypothalamic leptin signaling, Chronobiology International,
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      ChronobiologyHuman PhysiologyObesityCircadian Rhythms
The generation of humanized mouse models in which immune deficient mice are engrafted with human tissues allows for the direct in vivo investigation of human-restricted viruses. These humanized mouse models have been developed and... more
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      Humanized mouse modelsHCMV
Noninvasive functional imaging holds great promise for serving as a translational bridge between human and animal models of various neurological and psychiatric disorders. However, despite a depth of knowledge of the cellular and... more
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      NeuroimagingMagnetic Resonance ImagingMultidisciplinaryHumanized mouse models
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      ImmunologyBiotechnologyHematopoiesisSignal Transduction
Human Immune System (HIS) mice represent a novel biotechnology platform to dissect human haematopoiesis and immune responses. However, the limited human T-cell development that is observed in HIS mice restricts its utility for these... more
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      BiomedicineImmunologyBiotechnologyFlow Cytometry
Maytenus macrocarpa(chuchuhuasi) is native tree of the Peruvian Amazon used as traditional medicine for the treatment of many diseases, but its effect on the male reproductive system has not yet been elucidated. The aim of this study is... more
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      PeruHumanized mouse modelsMale InfertilitySperm Count
Malaria, which is the result of Plasmodium falciparum infection, is a global health threat that resulted in 655,000 deaths and 216 million clinical cases in 2010 alone. Recent phase 3 trials with malaria vaccine candidate RTS,S/AS01... more
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      ImmunologyMalariaHumanized mouse models
High grade gliomas are malignant brain tumors that arise in the central nervous system, in patients of all ages. Currently, the standard of care, entailing surgery and chemo radiation, exhibits a survival rate of 14-17 months. Thus, there... more
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      Clinical TrialCancer ImmunotherapyHumanized mouse modelsGlioma
Background: Passive transfer of antibodies not only provides immediate short-term protection against disease, but also can be exploited as a therapeutic tool. However, the 'humanization' of murine monoclonal antibodies (mAbs) is a... more
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      BiomedicineImmunologyBiotechnologyFlow Cytometry
Efficient delivery of drugs to specific cellular reservoirs is of particular importance for therapeutics that are not able to pass cellular barriers and that may have unwanted side effects in off-target tissues. Heparin-binding epidermal... more
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      BiomedicineBiomedical EngineeringImmunologyBiotechnology
Klebsiella pneumoniae is a bacterial pathogen of worldwide importance and a significant contributor to multiple disease presentations associated with both nosocomial and community acquired disease. ATCC 43816 is a well-studied K.... more
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    •   5  
      GenomicsNext generation sequencingHumanized mouse modelsPneumonia
Malaria, which is the result of Plasmodium falciparum infection, is a global health threat that resulted in 655,000 deaths and 216 million clinical cases in 2010 alone. Recent phase 3 trials with malaria vaccine candidate RTS,S/AS01... more
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      ImmunologyMalariaHumanized mouse modelsLiver
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      MicrobiologyBiomedicineImmunologyBiotechnology
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      ImmunologyHIV/AIDSVirologyMolecular virology
Children exposed to ionizing radiation have a substantially greater breast cancer risk than adults; the mechanism for this strong age dependence is not known. Here we show that pubertal mammary glands exposed to sparsely or densely... more
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      Stem CellsComputational BiologyAgent Based SimulationSystems Biology
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      BiomedicineImmunologyBiotechnologyFlow Cytometry
Infusion of regulatory T cells (Tregs) engineered with a chimeric antigen receptor (CAR) targeting donor-derived human leukocyte antigen (HLA) is a promising strategy to promote transplant tolerance. Here, we describe an anti-HLA-A2 CAR... more
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      ImmunologyOrgan Donation and TransplantationT cell receptorTregs
Abnormalities of cardiomyocyte Ca 2+ homeostasis and excitation–contraction (E–C) coupling are early events in the pathogenesis of hypertrophic cardiomyopathy (HCM) and concomitant determinants of the diastolic dys-function and... more
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      Humanized mouse modelsTwo-photon MicroscopyCardiomyocytesCardiomyopathy
In all living organisms trace element metabolism and transport are closely regulated at the genetic level. Copper is one of the essential microelements required for normal growth and development. The main organ in mammals involved in... more
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      Evolutionary BiologyGeneticsZoologyAging
The efficient control of gene expression in vivo from lentiviral vectors remains technically challenging. To analyze inducible gene expression in a human setting, we generated 'human immune system' (HIS) mice by transplanting newborn... more
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      ImmunologyBiotechnologyGene TherapyGene expression
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      MicrobiologyBiomedicineImmunologyBiotechnology
BACKGROUND: Staphylokinase (SAK) is produced by the majority of Staphylococcus aureus strains. It is an extracellular protein that activates the conversion of human plasminogen (plg) to plasmin. The role played by SAK in staphylococcal... more
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      Infectious DiseasesHumanized mouse modelsStaphylococcus aureusStaphylokinase
Tumor suppressor p53 plays an important role in regulating cell cycle progression and apoptosis. Here we applied RNA interference to study the role of p53 in human hematopoietic development in vivo. An siRNA construct specifically... more
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      ImmunologyBiotechnologyFlow CytometryGene Therapy
Cytokine immunotherapies targeting T lymphocytes are attractive clinical interventions against viruses and tumors. In the mouse, the homeostasis of memory α/β CD8(+) T cells and natural killer (NK) cells is significantly improved with... more
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      BiomedicineImmunologyBiotechnologyInfectious Diseases
BACKGROUND: Staphylococcus aureus (S. aureus) is a frequent cause of skin and soft tissue infections. A unique feature of S. aureus is the combined presence of coagulases that trigger fibrin formation and of the plasminogen activator... more
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      Humanized mouse modelsStaphylococcus aureusSkin DiseasesPlasminogen