Effects of kainate treatment on hippocampal morphology

<p>Photomicrographs of representative Nissl-stained coronal sections containing the dentate gyrus, CA3 and CA1 hippocampal fields taken from a control rat (<b>A</b>), from a rat in the behavioral status epilepticus (BSE) group (<b>B</b>) and from a kainate-treated rat that had not experienced behavioral status epilepticus (no-BSE; <b>C</b>). Note that the density of neurons in the dentate hilus is considerably reduced in the rats with (<b>B</b>) and without (<b>C</b>) behavioral SE when compared to the control rat (<b>A</b>). Note also dramatic loss of the CA3 and especially CA1 neurons in the rat from the BSE group; neurons in the CA2 field are relatively preserved (<b>B</b>). Scale bar shown in (<b>B</b>) = 200 µm.</p