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Biocosmology

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In 1978 I proposed the biocosmological thesis that the form of life's origin and evolution is a cosmological interactive process defined in the cosmic symmetry-breaking at the origin of the universe. With the passage of time, the pendulum has shifted from the improbability of life as a random molecular accident to an awareness that central biomolecules may be cosmologically abundant products of the clouds forming young stars leading to an RNA-era in which both catalysis and replication emerged from one cosmologically derived molecule RNA. This paper unveils the non-linear quantum foundations of biocosmology as the founding science of life.

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Koichiro Matsuno

Biosystems, 1997

The physical origin of life addresses itself to a semantic process on material grounds, in which causation toward contextualization is at work. Physically semantic process of whatever kind is specific in that every material participant is searching and modifying the material context to be fitted in. Fundamental to the physical semantics is the process of measurement proceeding internally among the constituent material participants, whereas the molecular syntax alone as embodied in the form of the quantum-mechanical equation of motion supplemented independently by exogenous boundary conditions cannot cope with the material process underlying the origin. A basic physical attribute of the phenomenon called life is variable duration, in contrast to invariant duration of Galilean. inertia. In fact, molecular replication thought as a harbinger of the phenomenon of life is a concrete form of variable duration and could be established unless internal measurement being instrumental to physically semantic process is forcibly eliminated by some external means. Physical experiments on the onset of molecular replication could become feasible only when external controllability over the intended experiments even at nano-meter scales is abandoned so as to save the room of internal measurement on the part of participating molecules.

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Theory of the Origin, Evolution, and Nature of Life
Erik Andrulis

Life is an inordinately complex unsolved puzzle. Despite significant theoretical progress, experimental anomalies, paradoxes, and enigmas have revealed paradigmatic limitations. Thus, the advancement of scientific understanding requires new models that resolve fundamental problems. Here, I present a theoretical framework that economically fits evidence accumulated from examinations of life. This theory is based upon a straightforward and non-mathematical core model and proposes unique yet empirically consistent explanations for major phenomena including, but not limited to, quantum gravity, phase transitions of water, why living systems are predominantly CHNOPS (carbon, hydrogen, nitrogen, oxygen, phosphorus, and sulfur), homochirality of sugars and amino acids, homeoviscous adaptation, triplet code, and DNA mutations. The theoretical framework unifies the macrocosmic and microcosmic realms, validates predicted laws of nature, and solves the puzzle of the origin and evolution of cellular life in the universe. Life 2012, 2 2

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The origin of life: what we know, what we can know and what we will never know
Addy Pross

Open biology, 2013

The origin of life (OOL) problem remains one of the more challenging scientific questions of all time. In this essay, we propose that following recent experimental and theoretical advances in systems chemistry, the underlying principle governing the emergence of life on the Earth can in its broadest sense be specified, and may be stated as follows: all stable (persistent) replicating systems will tend to evolve over time towards systems of greater stability. The stability kind referred to, however, is dynamic kinetic stability, and quite distinct from the traditional thermodynamic stability which conventionally dominates physical and chemical thinking. Significantly, that stability kind is generally found to be enhanced by increasing complexification, since added features in the replicating system that improve replication efficiency will be reproduced, thereby offering an explanation for the emergence of life's extraordinary complexity. On the basis of that simple principle, a f...

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The RNA World and Divine Action in and Through Quantum Mechanics
Daekyung Jung

Theology and Science, 2018

Life emerged on Earth approximately 4.1 billion years ago. Current scholarship on the origin of life supports the RNA world scenario, although controversy still goes on. This article examines the origin issue in light of a divine action theory proposed by Robert J. Russell. Although the author himself has not much considered the issue in light of the divine action, the article is still fruitful in the sense that the origin of life issue is now incorporated into the dialogue with divine action, and also that Russell's divine action theory can be reconsidered in a new context.

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2017.09.18 Biological Life is a purely quantum phenomenon.
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2017.09.18 Biological Life is a purely quantum phenomenon., 2017

The primary quantum basis of biological life is found. The process of the origin of life is restored.

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Quantum mechanics, heredity and the origin of life*
Howard H Pattee

Journal of Theoretical Biology, 1967

A macroscopic physical system which represents a classification process requires a non-holonomic constraint. . A molecular representation of a non-holonomic constraint requires a specific rate control process or tactic catalysis. It is concluded that a quantum theory of measurement is needed to explain enzymes as well as the reliability of biological evolution.

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Origins of Life: Chemical and Philosophical Approaches
Vera Kolb

Evolutionary Biology, 2015

In this article we address selected important milestones of chemical evolution that led to life. The first such milestone could be achieved by Oparin's model, which accounts for the early stages of chemical evolution. These occurred at the dawn of development of primitive chemical systems that were pre-RNA. Oparin's model consists of spontaneous formation of coacervates that encapsulate chemical matter, undergo primitive self-replication, and provide a pathway to a primitive metabolism. We review the experimental updates of his model from our laboratory and discuss types of selection that could have occurred in these primitive systems. Another major milestone in chemical evolution is the transition from abiotic to biotic. This has occurred later, after the RNA world evolved. A controversy of what life is interferes with the efforts to elucidate this transition. Thus, we present various definitions of life, some of which specifically include the requirements and mechanisms for this transition. Selfreplication is one of the major requirements for life. In this context we reexamine the question if viruses, which do not have capability to self-replicate, are alive. We draw on philosophy of Hegel, Aristotle, Rescher, Priest, and Fry to guide us in our endeavors. Specifically, we apply Hegel's law on quantity-to-quality transition to abiotic-to-biotic transition, Aristotle's philosophy to the definition of life, Priest's dialetheism to the question if viruses are alive or not, Fry's philosophy to the beginning of natural selection in chemical evolution, and Rescher's philosophy to the possible cognitive bias toward simple definitions of life.

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Physical theories, automata, and the origin of life
Howard H Pattee

Natural automata and useful simulations. Washington: …, 1996

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Prebiological evolution and the physics of the origin of life
antonio lazcano

Physics of Life Reviews, 2005

The basic tenet of the heterotrophic theory of the origin of life is that the maintenance and reproduction of the first living systems depended primarily on prebiotically synthesized organic molecules. It is unlikely that any single mechanism can account for the wide range of organic compounds that may have accumulated on the primitive Earth, suggesting that the prebiotic soup was formed by contributions from endogenous syntheses in reducing environments, metal sulphide-mediated synthesis in deep-sea vents, and exogenous sources such as comets, meteorites and interplanetary dust. The wide range of experimental conditions under which amino acids and nucleobases can be synthesized suggests that the abiotic syntheses of these monomers did not take place under a narrow range defined by highly selective reaction conditions, but rather under a wide variety of settings. The robustness of this type of chemistry is supported by the occurrence of most of these biochemical compounds in the Murchison meteorite. These results lend strong credence to the hypothesis that the emergence of life was the outcome of a long, but not necessarily slow, evolutionary processes. The origin of life may be best understood in terms of the dynamics and evolution of sets of chemical replicating entities. Whether such entities were enclosed within membranes is not yet clear, but given the prebiotic availability of amphiphilic compounds this may have well been the case. This scheme is not at odds with the theoretical models of self-organized emerging systems, but what is known of biology suggest that the essential traits of living systems could have not emerged in the absence of genetic material able to store, express and, upon replication, transmit to its progeny information capable of undergoing evolutionary change. How such genetic polymer first evolved is a central issue in origin-of-life studies.

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The origins of life: novel perspectives over an old problem
Roberto Ligrone

Bulletin of Regional Natural History (BORNH), 2021

Life probably appeared on Earth around 4 billion years ago and was globally diffused within the next 500 million years. It is debated whether life emerged in a superficial terrestrial environment, as generally maintained by "primordial-soup" models, or in association with submarine hydrothermal vents. Simulation experiments show that abiotic formation of simple organic molecules from CO 2 and H 2 , and of peptides from free amino acids is thermodynamically favoured under hydrothermal-vent conditions. In contrast, proposed pathways of abiotic synthesis of nucleotides and RNA fit better with superficial scenarios subject to wet/dry cycles. The "RNA World" hypothesis posits that a critical step towards life was the appearance of RNA enzymes (ribozymes) that catalysed RNA replication and random α-amino acid polymerization. The narrative presented here suggests that ribozyme interaction with peptides underpinned the emergence of populations of "protoribosomes" and virus-like RNA "protochromosomes" depending on each other for replication and subject to Darwinian evolution. The establishment of a genetic code coupled RNA and peptide evolution. RNA chaperoning of peptides positively selected self-folding peptide sequences, thus paving the way to the evolution of biologically active protein architectures. Association of informationally interlinked protoribosomes BORNH Review Article 12

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