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Psoriasis İle Hepatit C Virus Enfeksiyonu İlişkisi

2003, Turkiye Klinikleri Journal of Dermatology

AI-generated Abstract

Psoriasis ile Hepatit C virüs enfeksiyonu arasındaki ilişkiyi inceleyen araştırma, bu iki durumun etiyolojisi ve patofizyolojisi üzerindeki etkileşimleri analiz etmektedir. Psoriasis hastalarının Hepatit C virüs enfeksiyonu ile olan bağlantısı, klinik verilerle desteklenmekte ve olası mekanizmalar tartışılmaktadır. Çalışma sonuçları, Psoriasis'in Hepatit C hastalığı riskini etkileyebileceğini ve ilacın tedavi süreçlerindeki rolünü ortaya koymaktadır.

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