Evaluation of Profenofos Intoxication In White Rats

Profenofos is an organophosphorous insecticide which extensively used in agriculture and household. The present work is under taken to evaluate acute, subchronic and withdrawal effects of profenofos intoxication on some lipid metabolism indices and cytotoxicity enzymes biomarkers as well as on total non-specific esterase in blood of male white rats. Adult male white rats weighing 200±20 g were orally administered with Profenofos at single dose of 47.5mg/kg body weight or repeated dose of 23.75mg/kg body weight. Exposure to single or repeated doses of Profenofos elicited significant increase in TC, TG and LDL-C levels parallel to a decrease in HDL-C level. Also, induction of AcP, ALP, LDH and CK activities were recorded throughout most of the experiments periods as compared to corresponding controls at confidence interval 95% or P >0.05 respectively. Pointed to the withdrawal effect; all the parameters under investigation restored near the control values except for HDL-C and LDL-C...