P.162 Analgesic action of laser therapy in an animal model

S208 Journal of Cranio-Maxillofacial Surgery 36(2008) Suppl. 1 Swelling was the most frequent chief complaint (39%), followed by pain (22%). However, 18% of the cases were symptomless. Among 171 surgically treated odontogenic tumors, enucleation with or without curettage was performed in 125 cases (65.1%). At least 5 cases of ameloblastoma and 4 cases of keratocystic odontogenic tumor recurred. Abstracts, EACMFS XIX Congress poor dental health increases the risk of spontaneous spread of infection. Poor dental health appears to correlate with a stronger immune response as reflected by higher CRP-levels and WBCcounts during the infection course. P.162 Analgesic action of laser therapy in an animal model P.160 Adverse drug reactions in oral and maxillofacial surgery T. Kaczmarzyk1 , J. Woron2 . 1 Dept. of Oral Surgery, 2 Regional Centre For Adverse Drug Reactions Monitoring Medical College, Jagiellonian University, Krakow, Poland Antibiotics and analgesics are the most commonly prescribed drugs by oral and maxillofacial surgeons. Unwanted and dangerous adverse drug reactions constitute very important problem in contemporary medicine which is, unfortunately, very often neglected. Medicines prescribed by oral and maxillofacial surgeons very often lead to these reactions. Only in 12 months (between January and December 2007), the Regional Centre for Adverse Drug Reactions Monitoring in Krakow, Poland received 71 reports of dangerous, adverse reactions caused by drugs prescribed in oral and maxillofacial surgery departments. Of these, 54 (76%) were induced by analgesics and 17 (24%) by antibiotics. The most common analgesic that provoked dangerous reactions was ketoprofen (21 reports), followed by metamizole (15 reports). The reported complications were: nausea, vomiting, gastrotoxicity, hepatic disorders, oedema, transient hypertension, diaphoresis, brochoconstriction and anaphylactic reaction. Among antibiotics, clindamycin were the one to cause dangerous, unwanted reaction most often (11 reports), followed by amoxicillin/clavulanic acid (4 reports). The reported complications were: diarrhoea, nausea, vomiting, dehydratation and urticaria. However, no reports on pseudomembranous collitis induced by these antibiotics were received. Presented paper describes possible adverse reactions resulting from analgesic and antibiotic pharmacotherapy in oral and maxillofacial surgical practice and their risk factors. P.161 Aetiology of odontogenic maxillofacial infections L. Seppänen, K. Lemberg, A. Lauhio, C. Lindqvist, R. Rautemaa. Haartman Institute, Helsinki, Finland Objectives: To analyse the aetiology and presentation of odontogenic maxillofacial infections requiring hospital care. Methods: Medical records of 84 patients admitted to our hospital due to odontogenic maxillofacial infection in 2004 were analysed. Age, gender, occupational social class, medical status, body temperature, infection parameters, dental foci, preceding treatment, fascial spaces involved, need for reoperation, need for intensive care, length of stay, and preoperative panoramic radiographs were reviewed. Results: A dental procedure preceded the spreading of the infection in most cases (n = 49): endodontic treatment (n = 22), tooth extraction (n = 19), and restorative or other non-invasive treatment (n = 8). Spontaneous spreading occurred in 27 patient cases. Antimicrobial treatment without any dental procedures had been given to eight patients. Apical periodontitis was the most common source of infection in all cases (p = 0.0030). Patients with spontaneous spreading of the infection had significantly poorer dental health than other patients (p = 0.0004). These patients had the highest CRP-levels and WBC-counts on admission (p = 0.0197 and p = 0.0107). This group also had most patients with roots and the highest mean number of roots per patient (p = 0.0009 and p = 0.0491). Conclusions: Odontogenic maxillofacial infections seem to be mainly complications resulting from dental procedures. However, R. Block Veras, D. Humberto Pozza, J. Batista Blessmann Weber, M. Gerhardt De Oliveira, M. Andre Matos De Oliveira, N. Ribeiro Neto, J. Batista De Macedo Sobrinho. Martin Luther University Halle-Wittenberg, Halle (Saale), Germany We evaluated the analgesic effect of laser therapy on healthy tissue of mice. Forty-five animals were divided in three groups of 15: A infrared laser irradiation; B red laser irradiation; C sham irradiation with laser unit off. After laser application, the mice remained immobilized for the injection of 30 l of 2% formalin in the plantar pad of the irradiated hindpaw. The time that the mouse kept the hindpaw lifted was measured at 5 min intervals for 30 minutes. Results showed statistically significant differences comparing the control group with the infrared laser group at 5, 20, 25 and 30 accumulated minutes, and with the red laser group at all time points. The analysis of partial times, at each 5 minutes, showed statistically significant differences between the control and the laser groups up to 20 minutes. Laser therapy had an analgesic effect and red laser had the best results. P.163 Anatomic assessment of anterior mandible in human cadavers G. Rosano, S. Taschieri1 , M. Del Fabbro1 , T. Testori1 , A. Antifora1 , J-F. Gaudy2 . 1 Galeazzi Institute, Department of Health Technologies, University of Milano, Milan, Italy; 2 Head of Section of Department of Cranial Cervicofacial Anatomy, University of Paris, France Objectives: The aim of the present article was to evaluate the incidence, size, location and content of the foramina and bony canals located on the lingual side of the mandibular midline. Methods: The study consisted of 60 human cadavers (age at death 55 to 85 years), with equal gender distribution. 60 dry human mandibles were morphometrically analyzed by measuring incidence and size of these foramina and their distances from the mandibular base on the lingual side using a digital sliding calliper. The midline foramina were classified into superior and inferior genial spinal foramina according to their vertical location with respect to the genial spines. In addition, macroanatomic dissection was performed on another 20 intact mandibular specimens to investigate the canal contents associated with the foramina. Results: All of the 60 dry mandibles investigated had at least one lingual foramen. Evaluation of the macroanatomical dissections indicated a clear vascular bundle in both superior and inferior genial spinal foramina and canals. For the superior canal, the content was found to derive from the lingual artery; for the inferior one, the arterial origin was submental and/or sublingual. Conclusions: Implant and oral surgery operations in the interforaminal region are not therefore free from complications of haemorrhagic type, though these are exceptional. As a matter of fact, several of the arteries associated with accessory lingual mandibular foramina are of sufficient size to be implicated in severe hemorraging episodes in the floor of the mouth during implant placement in the mandibular anterior region.