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PCL and PCL-Based Materials in Biomedical Applications

PCL and PCL-Based Materials in Biomedical Applications

Journal of biomaterials science. Polymer edition, 2017
Aysel  Kızıltay
Abstract
Biodegradable polymers have met withan increasing demand in medical usage over the last decades. One of such polymers is poly(ε-caprolactone) (PCL), whichis a polyester that has been widely used in tissue engineering field for its availability, relatively inexpensive price and suitability for modification. Its chemical and biological properties, physicochemical state, degradability and mechanical strengthcan be adjusted, and therefore,it can be usedunderharsh mechanical, physical and chemical conditions without significant loss of its properties. Degradation time of PCL is quite long, thus it is used mainly in the replacement of hard tissues inthe body where healing also takes an extended period of time. It is also used at load-bearing tissues of the body by enhancing its stiffness. However, due to its tailorability, use of PCL is not restricted to one type of tissueand it can be extended to engineering of soft tissues by decreasing its molecular weight and degradation time. This re...

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