Calculo multivariable

Academia Biology, 2024

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline and behavioral disturbances. The pathogenic characteristics encompass the existence of amyloid plaques outside the cells, neurofibrillary tangles inside the cells, neuroinflammation, oxidative stress, and the loss of synapses. The altered brain endocannabinoid system (ECS) has been linked to the progression of AD. The ECS consists of endocannabinoids, metabolic enzymes, and their receptors, CB1R and CB2R. Individuals have utilized therapeutic cannabis-derived remedies for medicinal purposes. The cannabis plant is composed of a diverse range of phytocannabinoids, terpenes, and phenolic compounds. Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are plant-derived compounds that have been well researched. Both phytocannabinoids contribute to physiological and pharmacological effects. Multiple preclinical studies conducted on animal models of AD have shown that THC specifically targets and modifies the pathological markers of AD while simultaneously enhancing cognitive function. Studies have shown that administering low amounts of THC can reduce the phosphorylation of tau, the accumulation of beta-amyloid proteins, and the levels of GSK3 beta. Moreover, it has the potential to enhance mitochondrial function. Furthermore, a study has shown that maintaining a balance between CB1R and CB2R is essential for stability in neuroinflammation, neurogenesis, and cognitive performance. At present, numerous FDA-controlled clinical trials are being conducted to assess the beneficial impacts of THC and CBD in the treatment of cognitive and neuropsychiatric symptoms associated with AD. This review article focuses on the therapeutic advantages of phytocannabinoids and their role in AD, the most common neurodegenerative disease.

1994

خطابات, 2024

تبحث هذه الدراسة في خطابٍ متعلّقٍ بنقاشٍ اجتماعي طويل الأمد حول سلامة الأغذية المعدلة وراثيا في الصين. وهي تستند إلى بيانات مأخوذة من منصة التواصل الاجتماعي ويشات ) ،)WeChat معتمدةً منظور التحليل النقدي للخطاب لتحليل الإستراتيجيات المستخدمة في الخطابات المتعلقة بهذه الأغذية، ولبناء هويات الطرفين المتعارضين في النقاشات المتعلقة بها. وقد وظّف هذان الطرفان أدوات بلاغية متعددة وإستراتيجيات حجاجية مختلفة وعناصر تاريخية تناصية متنوعة، إذ يميل الطرف المعارض لهذه الأغذية إلى استخدام الاستعارات والتخليق ) moralization ( والأمثال المتناصة ) )intertextual والنبرات الثورية لإضفاء الشرعية على موقفه، في حين يستخدم الطرف المؤيد غالبا السخرية والتفويض authorization والإشارات التاريخية لإضفاء الشرعية على هيمنته وتعزيزها. أقترح أن استكشاف كيفية بناء كل طرف للخطاب بشكل إستراتيجي قد يسهل فهمًا أفضل، ويخفف من الصراع بين وجهتي النظر المتضاربتين والممثَّلَتين في وسائل التواصل الاجتماعي.

2016

Una labor de sintesis alrededor de la gran tematica de este libro que surge a partir de una serie de reflexiones y propuestas encaminadas desde la innovacion del diseno para el desarrollo social, refleja una invitacion al lector para enunciar a partir de su lectura nuevas discusiones sobre el quehacer del diseno con una perspectiva de innovacion para este tipo de desarrollo, es pues este texto una invitacion a enunciar nuevos retos y dialogos partiendo de reconocer al desarrollo social como uno de los pilares fundamentales desde la Organizacion de las Naciones Unidas (ONU) como parte fundamental para garantizar el mejoramiento de la vida de las personas. Desde la disciplina del diseno y retomado como eje para su discusion se pretenderia establecer una serie de reflexiones y acciones que permitan atender situaciones para grupos minoritarios y vulnerables, asi como apoyar esfuerzos encaminados a mejorar la calidad de vida de los integrantes de grupos y sociedades establecidas y recupe...

Protestantesimo 79, 2-3, 109-116, 2024

I commenti di Rashì, da quasi un millennio, rappresentano il primo obbligato riferimento per chi intende spiegare il testo biblico, non solo in campo ebraico. È nota l'influenza dei commenti di Rashì sull'opera di Nicola di Lyra, che li citò ampiamente, tanto da meritarsi il sarcastico soprannome di Simia Salomonis 1. Nicola di Lyra sarà poi letto e citato da Martin Lutero. Studi recenti sostengono che il commento di Rashì abbia persino influenzato la cosiddetta King James 2. Lo storico Avraham Ben David, afferma che «Da quando i suoi commenti si sono diffusi nel mondo, non c'è stato rabbino o uomo eminente che abbia studiato il Talmud senza di lui. Nessun rabbino, nessun maestro ne ha visto mai di uguali» 3. Levy nota che «virtualmente qualsiasi commento tradizionale alla Torah che sia stato scritto dal medioevo risponde, in parte, ai commenti di Rashì» 4. Negli ultimi anni, dopo una fase in cui gli studi scientifici sul testo biblico sono stati quasi monopolizzati dalla pubblicazione di testi ugaritici, egiziani e accadici, che hanno condotto gli studiosi principalmente a cercare il «corretto» significato delle Scritture, a seguito di una fase in cui l'interesse era focalizzato sull'esegesi biblica medievale, per via della scoperta della Ghenizah del Cairo, dei rotoli del mar Morto e di al

A Companion to Contemporary Political Philosophy

Based on the ancient Greek words cosmos (world) and polites (citizen), a cosmopolitan is a citizen of the world. The more common modern meaning closely refl ects these ancient roots. Persons are called cosmopolitans, or cosmopolitan, when they are understanding and respectful of foreign cultures, travel widely, and can interact well with people from many societies. And cities or gatherings are called cosmopolitan when they bring together persons and groups with diverse ethnicities, languages, cultures, religions or lifestyles. Like other-isms, cosmopolitanism is an intellectual position-or, more precisely, a family of such positions. With aesthetic considerations standing in the way of calling such a position and its adherents 'cosmopolitanist' (in analogy to 'perfectionist' and 'materialist'), the word 'cosmopolitan' has assumed a second meaning: characterizing a theory or person committed to cosmopolitanism. Only this second meaning of 'cosmopolitan' concerns us here. Unlike some other-isms, cosmopolitanism involves not merely views about how things are, but primarily views about how things ought to be. Cosmopolitan positions centrally include evaluative and normative views; they assess and prescribe. The central idea guiding these moral assessments and prescriptions is that of including all human beings as equals. This central idea can be understood and employed in diverse ways, and a variety of cosmopolitan positions can therefore be distinguished. This variety can be reconstructed in two steps. In a fi rst step, one distinguishes topically the various subject matters to which the central cosmopolitan idea can be applied. In a second step, one can then distinguish, within each subject matter, different ways of understanding and applying the central cosmopolitan idea. Focusing on the fi rst step, let me distinguish four main kinds of cosmopolitanism, each of which will then be more fully discussed in a subsequent section. To motivate this distinction, we can start out from the way moral conceptions are generally categorized according to the types of entities, or iudicanda, for which they provide assessments and prescriptions. Such iudicanda are of four main types: individual and collective agents, the conduct of such agents, social institutions (rules, practices) and states of the world. Ways of assessing agents and their conduct are closely interrelated and therefore usually treated together in what may be called a conception of ethics. Such a conception GOO12.indd 312 GOO12.indd 312 2007/3/26

karwinskii y A. potatorum, explotadas de manera no sostenible para la elaboración de mezcal. El objetivo fue disponer de una herramienta que permita la conservación a mediano plazo de germoplasma de estas especies. Se demostró que la adición de agentes osmóticos al medio de cultivo (manitol o sorbitol 50 g L -1 ) es capaz de reducir la tasa de crecimiento in vitro de los tejidos, medida como incremento en peso fresco, y prolongar así el tiempo entre subcultivos de 75 d a 10 meses, y sin afectar su viabilidad ni su capacidad de regenerar plantas completas en medios con citocininas y sin los agentes osmóticos. Se obtuvieron eficiencias de regeneración de entre 5.8 y 20.6 brotes por explante en tejidos conservados durante 10 meses con la adición de agentes osmóticos. Los brotes generados formaron raíces y se adaptaron a suelo con eficiencias de 92 y 80 % en promedio, respectivamente. Se concluye que con este sistema es posible establecer a mediano plazo bancos de germoplasma in vitro que contribuyan a la conservación y uso racional de estas especies.

Informe sobre retirada de escudo BRAH 2021 E Moradiellos. , 2021

Informe de E. Moradiellos sobre la retirada de un escudo tallado en piedra de la fachada de la Casa Consistorial del municipio de Palacios Rubios (Salamanca", publicado en el Boletín de la Real Academia de la Historia, tomo 228, cuaderno 3, 2021, pp. 762-764.

Biomass energy is one of the alternative sources of energy, which is particularly accessible in huge quantity worldwide in rural areas. Globally, solid biomass waste is the fourth as an energy resource after coil, oil and gas, which was providing approximately 14% of the world's energy needs. The potential of biomass materials depends on feedstock quantities and their composition. The use of biomass materials as energy source provides extensive benefits as far as the environment is concerned. The agricultural biomass materials absorb carbon dioxide (CO 2) during growth and emit it during combustion. Utilization of these types of wastes in various applications is in the form of a renewable and CO 2-neutral fuel. The physicochemical and structural analyses of agricultural biomass differ significantly with the feedstock types. This review study provides an alternative approach and better understanding to utilize huge amount of energy stored in biomass as the substitute of fossil fuels and also it should play an important role in sustainable energy systems as a component of a renewable energy mix.

OBRA: FABRICACIÓN Y MONTAJE DE SETS, ESCALERAS Y TUBERÍAS EN RB-8892 MINA PARAGSHA -CERRO DE PASCO 1. CONTENIDO DEL PROYECTO. DENOMINACIÓN DEL PROYECTO: INSTALACIÓN DE TUBERÍAS PARA REPOTENCIACIÓN DEL SISTEMA DE BOMBEO CAMARA 8812 A TRAVES RAISE BORE 8892 HASTA RESERVORIO MIRAFLORES. DENOMINACIÓN DEL SUB PROYECTO: FABRICACION Y MONTAJE DE SETS, ESCALERAS Y TUBERIAS DE ACERO DE 16" Y 20" EN RB-8892 MINA PARAGSHA -CERRO DE PASCO.