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ENGINEERING BIOMEDICAL SYSTEMS

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The text outlines a course focused on Biomedical Engineering, emphasizing practical applications through final projects and homework assignments. Key topics include the development of an artificial heart, insulin delivery systems, and nerve guidance conduits. The course aims to provide a comprehensive understanding of the field, covering skills such as 3D printing, literature surveys, and teamwork. It features multiple speakers and active participation in projects, preparing students for real-world challenges in biomedical technologies.

Instructor: Dmitrijs Celinskis [email protected] TAs: Shannon Crowley [email protected] Travis Wallace [email protected] Jason A. Cook, et al. J Thorac Dis. 2015 https://giphy.com/search/heartbeat http://www.taringa.net/ EN GI N EERI N G BI OM ED I CAL SYSTEM S http://www.dekaresearch.com/ Chen et al., 2012 Nat. Materials I nt roduct ions I nt roduct ions • Name • Where are you from • Random fact or what do you like to do I nt roduct ions • Name • Where are you from • Random fact or what do you like to do Ent ry Survey Tim e & Place • Monday – Friday, 3:30-6:20 PM • July 17 – July 21 • Location: M-F: 85 Waterman St. (AKA BERT), Rm010 • Office hours (time and location TBA): – Any questions are always welcomed!!! – Shoot me an email for an in-person meeting Course goals and act ivit ies • Learn what can you be working on if you decide to pursue this subject – Broad overview of the field of Biomedical Engineering – Bringing diverse perspective: 9 speakers • Learn a variety of skills – – – – – – – 3D printing Literature survey Wet lab techniques Presentation skills Electrical biopotential recording Working with tissue samples Teamwork Final proj ect s • 6 groups of 3 • Final project splits into multiple homeworks – Homeworks will be posted on Canvas – Example questions: • What is the device? How does it work? • How will you improve it? • How will you test it? • By the end of the course: – Written document (3-5 pages) – Presentation on Friday • 10 minutes + 2 minutes for Q/A Topics • Knee implant: Vanguard knee replacement – 30 million of patients affected by osteoarthritis [www.cdc.gov] www.kneereplacement.com/DePuy_technology http://www.preservingknee.com/ Video Topics • Insulin Delivery: DRI BioHub – “Artificial pancreas” = biological cure to restore natural insulin production for diabetic patients – Replacing “islet” cells through tissue engineering scaffolds – 29.1 million people have diabetes in the US alone [www.cdc.gov] http://www.diabetesresearch.org/BioHub-FAQ Topics • Nerve guidance conduits: NeuraGen® (Integra) – Absorbable implant for peripheral nerve repair – Causes: trauma, medical disorders – 20 million cases in the US alone [G. Lundborg, J. Peripheral Nervous System 2003] http://www.ilstraining.com/ Topics • Artificial heart: AbioCar – Designed to sustain the life of the patients who would otherwise die from heart failure – 3,000 heart transplantations per year in the US [www.ncbi.nlm.nih.gov] http://www.texasheart.org/Research/Devices/abiocor.cfm Topics • Deep brain stimulation for Parkinson’s disease: Activa RC neurostimulator – Treats tremor, rigidity, stiffness, slowed movement, and walking problems – 60,000 new cases per year in the US [www.pdf.org] http://www.medtronic.com Topics • Robotically assisted stomach surgery: da Vinci system – Facilitates complex surgeries using minimally invasive approach – 28,000 new stomach cancer cases annually [www.seer.cancer.gov] http://www.davincisurgery.com/ Rank t he t opics • You can have more than 1 favorite topic • Groups will be announced by the end of the class Cardiovascular syst em by Travis Wallace https://giphy.com/search/heartbeat Final proj ect groups Knee implant Nerve guidance conduit Artificial heart Insulin delivery Da Vinci Deep brain stimulation Ananya Alleyne Olivia Hanselman Karen Corbani Annika Stickels Michelle Bernard Seth DuBridge Matthew Dolan Doruk Kural Meira Farhi Tamami Tamura Noelle Guan Nicole Fraynd Alison Bacon Katherine Freeman Priya Merchia Dina Tolen Hom ework Questions: 1. Summarize the function of the biological system your device replaces/supplements/treats. 2. Describe the ailment your device replaces/supplements/treats. 3. What other similar devices are on the market? Expectations: 1. Work should be split up within groups 2. Submit your answers via Canvas before next class 3. Feel free (you should) to start working on slides for the final presentation