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A child with neck swelling

2012, BMJ (Clinical research ed.)

BMJ 2012;344:e3171 doi: 10.1136/bmj.e3171 (Published 8 May 2012) Page 1 of 3 Practice PRACTICE 10-MINUTE CONSULTATION A child with neck swelling 1 Ian P Sinha clinical lecturer and specialist registrar in paediatric respiratory medicine , Anna Stickland 2 3 general practitioner , Cheri Mathews John consultant paediatrician Department of Women’s and Children’s Health, Institute of Translational Medicine, University of Liverpool, Alder Hey Children’s Hospital, Liverpool L12 2AP, UK; 2Community Studies Unit, University of Liverpool, Liverpool L69 3GE; 3Department of Paediatrics, St Helens and Knowsley Teaching Hospitals NHS Trust, Liverpool L35 5DR 1 This is part of a series of occasional articles on common problems in primary care. The BMJ welcomes contributions from GPs A 5 year old boy presents with neck swelling and sore throat. He appears pale and tired, and has a 2 cm left sided neck swelling. What you should cover You should distinguish cervical lymphadenopathy secondary to local causes from other important diagnoses (box). Important features in the history • Local causes of lymphadenopathy—Ask about upper respiratory tract infections, earache, toothache, and headlice. Lymphadenopathy related to upper respiratory tract infections does not usually persist beyond three weeks of onset • Systemic illness—Fever, night sweats, weight loss, or pruritus may suggest malignancy or mycobacterial disease (tuberculous or non-tuberculous) • Recurrent infections—Immunodeficiency, including HIV infection, may cause generalised lymphadenopathy • Immunisations, particularly measles, mumps, and rubella (MMR) and BCG vaccines • Tuberculosis, risks or contact • Cats—Cat scratch disease (Bartonella henselae) and toxoplasmosis cause lymphadenopathy Important features of the examination General examination • Skin—Pallor, petechiae, or bruises may signify leukaemia. Excoriation may indicate lymphoma. Generalised rash may be caused by Kawasaki disease, adenovirus, cytomegalovirus, or Epstein-Barr virus. Cytomegalovirus and Epstein-Barr virus may cause jaundice. Kawasaki disease may cause peeling of skin around hands and feet. Scratches or indurations may indicate cat scratch disease • Generalised lymphadenopathy or hepatosplenomegaly may signify malignancy, Epstein-Barr virus, cytomegalovirus, or rheumatological conditions • Chest signs may signify mycobacterial infection, but these are often absent • Joint swelling, warmth, or tenderness may be caused by rheumatological conditions • Oropharynx—Tonsillar exudates increase the likelihood of bacterial tonsillitis. Examine for red, cracked lips (Kawasaki disease) and dental abscesses • Non-purulent conjunctivitis may be caused by Kawasaki disease or adenovirus. Neck examination: lymphadenomatous swellings • Viral upper respiratory tract infection usually causes multiple, bilateral, small (<2 cm) cervical lymphadenopathy. Lymphadenopathy secondary to bacterial upper respiratory tract infection may be unilateral, and larger (3–4 cm) • Pyogenic bacterial infection of lymph tissue (lymphadenitis) causes warm, tender, erythematous swelling. Fluctuance may suggest abscess formation • Posterior lymphadenopathy may signify Epstein-Barr virus or rubella • Malignancy may cause hard, immobile supraclavicular or axillary swelling • Diagnostic criteria for Kawasaki disease: more than one lymph node should measure >1.5 cm, lymphadenopathy should be non-fluctuant and non-suppurative. Correspondence to: I Sinha [email protected] For personal use only: See rights and reprints http://www.bmj.com/permissions Subscribe: http://www.bmj.com/subscribe BMJ 2012;344:e3171 doi: 10.1136/bmj.e3171 (Published 8 May 2012) Page 2 of 3 PRACTICE Differential diagnosis of neck swellings in children Lymphadenopathy (enlarged lymph nodes) Local causes • Viral or bacterial upper respiratory tract infection leading to lymphadenopathy* • Ear infection* • Oropharyngeal infection • Headlice infestation • Dental abscess • Cat scratch disease Systemic causes • Malignancy (lymphoma or leukaemia)* • Viral infections (Epstein-Barr virus, cytomegalovirus, rubella)* • Kawasaki disease* • Mycobacterial infection (tuberculous or non-tuberculous)* • Sarcoidosis • Systemic lupus erythematosus • Juvenile idiopathic arthritis Lymphadenitis (inflamed lymph nodes) or abscess • Bacterial lymphadenitis* • Mycobacterial lymphadenitis* • Abscess* Non-lymphadenomatous neck swellings • Cystic hygroma • Sternocleidomastoid swelling • Thyroid gland enlargement* • Thyroglossal cyst • Dermoid cyst • Branchial cyst • Mumps* *Commonly present to primary care with neck swelling or are particularly important diagnoses to consider Neck examination: findings suggestive of non-lymphadenomatous swellings • Swelling crosses the mandibular angle (mumps parotitis) • Midline swelling moving up with tongue protrusion (dermoid cyst, thyroglossal cyst) or swallowing (goitre) • Sternocleidomastoid swelling, which is smooth and mobile (branchial cyst) or is hard and associated with torticollis and a history of difficult delivery (sternomastoid “tumour”) If bacterial infection is suspected—Consider a 7–10 day course of phenoxymethylpenicillin (or macrolides for patients allergic to penicillin). Generalised or persistent lymphadenopathy—Perform screening blood tests: full blood count, blood film, erythrocyte sedimentation rate, liver function tests, and monospot test. (The monospot test can be falsely negative within the first week of infection and may remain positive for up to three months.) • Streptococcal throat infection or peritonsillar abscess Urgent referral to a paediatric team—If you suspect systemic illness or malignancy, or if fluctuance of the swelling leads you to suspect abscess formation. Swellings >3 cm should be referred acutely even if the child is otherwise well. Lymphadenopathy with hepatosplenomegaly requires immediate referral. Children without worrying clinical features whose swelling persists or reduces only slightly should be reviewed every one or two weeks and referred for further investigations if the swelling persists at four weeks. • Cystic hygroma We thank Drs David Unwin, Sarah Dunt, Ruth Brown, and Jody Brown for their involvement in discussions over GP management of this case. • Fluctuant, transilluminant swelling in the posterior triangle (cystic hygroma) Causes of massive neck swelling (refer urgently to hospital) • Epstein-Barr virus • Abscess What you should do Cervical lymphadenopathy secondary to viral upper respiratory tract infection—No treatment or investigation is required. Parents should return if the child becomes systemically unwell, or if, after seven days, the swelling has persisted or grown (this may signify non-infective swelling, or abscess formation). For personal use only: See rights and reprints http://www.bmj.com/permissions Contributors: IPS and CMJ had the idea for the article. All authors performed literature searches. IPS wrote the first draft of the article, and AS and CMJ contributed to subsequent drafts. IPS is the guarantor. All authors have completed the Unified Competing Interest form at http: //www.icmje.org/coi_disclosure.pdf (available on request from the corresponding author) and declare: no support from any organisation for the submitted work; no financial relationships with any organisations that might have an interest in the submitted work in the previous three Subscribe: http://www.bmj.com/subscribe BMJ 2012;344:e3171 doi: 10.1136/bmj.e3171 (Published 8 May 2012) Page 3 of 3 PRACTICE Further reading • Davenport M. ABC of general surgery in children. Lumps and swellings of the head and neck. BMJ 1996;312:368-71, doi:10.1136/ bmj.312.7027.368 • NHS Clinical Knowledge Summaries. Neck lump—management. www.cks.nhs.uk/neck_lump • Patient.co.uk. Neck lumps and bumps. www.patient.co.uk/doctor/Neck-Lumps-and-Bumps.htm • Choby BA. Diagnosis and treatment of streptococcal pharyngitis. Am Fam Physician 2009;79:383-90 years, no other relationships or activities that could appear to have influenced the submitted work. Cite this as: BMJ 2012;344:e3171 © BMJ Publishing Group Ltd 2012 Accepted: 22 February 2012 For personal use only: See rights and reprints http://www.bmj.com/permissions View publication stats Subscribe: http://www.bmj.com/subscribe